Human interleukin-23 receptor antagonists derived from an albumin-binding domain scaffold inhibit IL-23-dependent ex vivo expansion of IL-17-producing T-cells

Engineered combinatorial libraries derived from small protein scaffolds represent a powerful tool for generating novel binders with high affinity, required specificity and designed inhibitory function. This work was aimed to generate a collection of recombinant binders of human interleukin-23 recept...

Descripción completa

Detalles Bibliográficos
Autores principales: Kuchař, Milan, Vaňková, Lucie, Petroková, Hana, Černý, Jiří, Osička, Radim, Pelák, Ondřej, Šípová, Hana, Schneider, Bohdan, Homola, Jiří, Šebo, Peter, Kalina, Tomáš, Malý, Petr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285857/
https://www.ncbi.nlm.nih.gov/pubmed/24549990
http://dx.doi.org/10.1002/prot.24472

Ejemplares similares

Ejemplares similares