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ABCB1 Gene Polymorphisms and Glucocorticoid-Induced Avascular Necrosis of the Femoral Head Susceptibility: A Meta-Analysis
BACKGROUND: The results of studies on association between ABCB1 gene polymorphisms and glucocorticoid-induced avascular necrosis of the femoral head (GANFH) are controversial. This study aimed to assess the association of ABCB1 gene polymorphisms with the risk of GANFH by conducting a meta-analysis....
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285923/ https://www.ncbi.nlm.nih.gov/pubmed/25544111 http://dx.doi.org/10.12659/MSM.891286 |
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author | Li, Zhigang Zhao, Dewei Wang, Benjie |
author_facet | Li, Zhigang Zhao, Dewei Wang, Benjie |
author_sort | Li, Zhigang |
collection | PubMed |
description | BACKGROUND: The results of studies on association between ABCB1 gene polymorphisms and glucocorticoid-induced avascular necrosis of the femoral head (GANFH) are controversial. This study aimed to assess the association of ABCB1 gene polymorphisms with the risk of GANFH by conducting a meta-analysis. MATERIAL/METHODS: The PubMed, Cochrane Library, and Embase databases were searched for papers that describe the association between ABCB1 polymorphisms and GANFH risk. Summary odds ratios and 95% confidence intervals (CI) were estimated based on a fixed-effects model or random-effects model, depending on the absence or presence of significant heterogeneity. RESULTS: A total of 5 studies and 833 patients were included in the final analysis. Significant differences were found for rs1045642 polymorphism in the comparisons of CC vs. CT+TT (OR, 1.462; 95% CI, 1.066–2.007; P=0.019), and rs2032582 polymorphism in the comparisons of GG vs. G(TA)+(TA)(TA) (OR, 1.548; 95% CI,1.063–2.255; P=0.023). CONCLUSIONS: The study demonstrated that the ABCB1 polymorphisms (rs1045642 and rs2032582) significantly reduced the risk of GANFH. |
format | Online Article Text |
id | pubmed-4285923 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-42859232015-02-26 ABCB1 Gene Polymorphisms and Glucocorticoid-Induced Avascular Necrosis of the Femoral Head Susceptibility: A Meta-Analysis Li, Zhigang Zhao, Dewei Wang, Benjie Med Sci Monit Meta-Analysis BACKGROUND: The results of studies on association between ABCB1 gene polymorphisms and glucocorticoid-induced avascular necrosis of the femoral head (GANFH) are controversial. This study aimed to assess the association of ABCB1 gene polymorphisms with the risk of GANFH by conducting a meta-analysis. MATERIAL/METHODS: The PubMed, Cochrane Library, and Embase databases were searched for papers that describe the association between ABCB1 polymorphisms and GANFH risk. Summary odds ratios and 95% confidence intervals (CI) were estimated based on a fixed-effects model or random-effects model, depending on the absence or presence of significant heterogeneity. RESULTS: A total of 5 studies and 833 patients were included in the final analysis. Significant differences were found for rs1045642 polymorphism in the comparisons of CC vs. CT+TT (OR, 1.462; 95% CI, 1.066–2.007; P=0.019), and rs2032582 polymorphism in the comparisons of GG vs. G(TA)+(TA)(TA) (OR, 1.548; 95% CI,1.063–2.255; P=0.023). CONCLUSIONS: The study demonstrated that the ABCB1 polymorphisms (rs1045642 and rs2032582) significantly reduced the risk of GANFH. International Scientific Literature, Inc. 2014-12-29 /pmc/articles/PMC4285923/ /pubmed/25544111 http://dx.doi.org/10.12659/MSM.891286 Text en © Med Sci Monit, 2014 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License |
spellingShingle | Meta-Analysis Li, Zhigang Zhao, Dewei Wang, Benjie ABCB1 Gene Polymorphisms and Glucocorticoid-Induced Avascular Necrosis of the Femoral Head Susceptibility: A Meta-Analysis |
title | ABCB1 Gene Polymorphisms and Glucocorticoid-Induced Avascular Necrosis of the Femoral Head Susceptibility: A Meta-Analysis |
title_full | ABCB1 Gene Polymorphisms and Glucocorticoid-Induced Avascular Necrosis of the Femoral Head Susceptibility: A Meta-Analysis |
title_fullStr | ABCB1 Gene Polymorphisms and Glucocorticoid-Induced Avascular Necrosis of the Femoral Head Susceptibility: A Meta-Analysis |
title_full_unstemmed | ABCB1 Gene Polymorphisms and Glucocorticoid-Induced Avascular Necrosis of the Femoral Head Susceptibility: A Meta-Analysis |
title_short | ABCB1 Gene Polymorphisms and Glucocorticoid-Induced Avascular Necrosis of the Femoral Head Susceptibility: A Meta-Analysis |
title_sort | abcb1 gene polymorphisms and glucocorticoid-induced avascular necrosis of the femoral head susceptibility: a meta-analysis |
topic | Meta-Analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285923/ https://www.ncbi.nlm.nih.gov/pubmed/25544111 http://dx.doi.org/10.12659/MSM.891286 |
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