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The Diagnostic Validity of the (13)C-Urea Breath Test in the Gastrectomized Patients: Single Tertiary Center Retrospective Cohort Study

BACKGROUND: This study was conducted to evaluate the diagnostic validity of the (13)C-urea breath test ((13)C-UBT) in the remnant stomach after partial gastrectomy for gastric cancer. METHODS: The (13)C-UBT results after Helicobacter pylori eradication therapy was compared with the results of endosc...

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Autores principales: Kwon, Yong Hwan, Kim, Nayoung, Lee, Ju Yup, Choi, Yoon Jin, Yoon, Kichul, Yoon, Hyuk, Shin, Cheol Min, Park, Young Soo, Lee, Dong Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Cancer Prevention 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285962/
https://www.ncbi.nlm.nih.gov/pubmed/25574466
http://dx.doi.org/10.15430/JCP.2014.19.4.309
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author Kwon, Yong Hwan
Kim, Nayoung
Lee, Ju Yup
Choi, Yoon Jin
Yoon, Kichul
Yoon, Hyuk
Shin, Cheol Min
Park, Young Soo
Lee, Dong Ho
author_facet Kwon, Yong Hwan
Kim, Nayoung
Lee, Ju Yup
Choi, Yoon Jin
Yoon, Kichul
Yoon, Hyuk
Shin, Cheol Min
Park, Young Soo
Lee, Dong Ho
author_sort Kwon, Yong Hwan
collection PubMed
description BACKGROUND: This study was conducted to evaluate the diagnostic validity of the (13)C-urea breath test ((13)C-UBT) in the remnant stomach after partial gastrectomy for gastric cancer. METHODS: The (13)C-UBT results after Helicobacter pylori eradication therapy was compared with the results of endoscopic biopsy-based methods in the patients who have received partial gastrectomy for the gastric cancer. RESULTS: Among the gastrectomized patients who showed the positive (13)C-UBT results (≥ 2.5‰, n = 47) and negative (13)C-UBT results (< 2.5‰, n = 114) after H. pylori eradication, 26 patients (16.1%) and 4 patients (2.5%) were found to show false positive and false negative results based on biopsy-based methods, respectively. The sensitivity, specificity, false positive rate, and false negative rate for the cut-off value of 2.5‰ were 84.0%, 80.9%, 19.1%, and 16.0%, respectively. The positive and negative predictive values were 44.7% and 96.5%, respectively. In the multivariate analysis, two or more H. pylori eradication therapies (odds ratio = 3.248, 95% confidence interval= 1.088–9.695, P = 0.035) was associated with a false positive result of the (13)C-UBT. CONCLUSIONS: After partial gastrectomy, a discordant result was shown in the positive (13)C-UBT results compared to the endoscopic biopsy methods for confirming the H. pylori status after eradication. Additional endoscopic biopsy-based H. pylori tests would be helpful to avoid unnecessary treatment for H. pylori eradication in these cases.
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spelling pubmed-42859622015-01-08 The Diagnostic Validity of the (13)C-Urea Breath Test in the Gastrectomized Patients: Single Tertiary Center Retrospective Cohort Study Kwon, Yong Hwan Kim, Nayoung Lee, Ju Yup Choi, Yoon Jin Yoon, Kichul Yoon, Hyuk Shin, Cheol Min Park, Young Soo Lee, Dong Ho J Cancer Prev Original Article BACKGROUND: This study was conducted to evaluate the diagnostic validity of the (13)C-urea breath test ((13)C-UBT) in the remnant stomach after partial gastrectomy for gastric cancer. METHODS: The (13)C-UBT results after Helicobacter pylori eradication therapy was compared with the results of endoscopic biopsy-based methods in the patients who have received partial gastrectomy for the gastric cancer. RESULTS: Among the gastrectomized patients who showed the positive (13)C-UBT results (≥ 2.5‰, n = 47) and negative (13)C-UBT results (< 2.5‰, n = 114) after H. pylori eradication, 26 patients (16.1%) and 4 patients (2.5%) were found to show false positive and false negative results based on biopsy-based methods, respectively. The sensitivity, specificity, false positive rate, and false negative rate for the cut-off value of 2.5‰ were 84.0%, 80.9%, 19.1%, and 16.0%, respectively. The positive and negative predictive values were 44.7% and 96.5%, respectively. In the multivariate analysis, two or more H. pylori eradication therapies (odds ratio = 3.248, 95% confidence interval= 1.088–9.695, P = 0.035) was associated with a false positive result of the (13)C-UBT. CONCLUSIONS: After partial gastrectomy, a discordant result was shown in the positive (13)C-UBT results compared to the endoscopic biopsy methods for confirming the H. pylori status after eradication. Additional endoscopic biopsy-based H. pylori tests would be helpful to avoid unnecessary treatment for H. pylori eradication in these cases. Korean Society of Cancer Prevention 2014-12 /pmc/articles/PMC4285962/ /pubmed/25574466 http://dx.doi.org/10.15430/JCP.2014.19.4.309 Text en Copyright © 2014 Korean Society of Cancer Prevention This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kwon, Yong Hwan
Kim, Nayoung
Lee, Ju Yup
Choi, Yoon Jin
Yoon, Kichul
Yoon, Hyuk
Shin, Cheol Min
Park, Young Soo
Lee, Dong Ho
The Diagnostic Validity of the (13)C-Urea Breath Test in the Gastrectomized Patients: Single Tertiary Center Retrospective Cohort Study
title The Diagnostic Validity of the (13)C-Urea Breath Test in the Gastrectomized Patients: Single Tertiary Center Retrospective Cohort Study
title_full The Diagnostic Validity of the (13)C-Urea Breath Test in the Gastrectomized Patients: Single Tertiary Center Retrospective Cohort Study
title_fullStr The Diagnostic Validity of the (13)C-Urea Breath Test in the Gastrectomized Patients: Single Tertiary Center Retrospective Cohort Study
title_full_unstemmed The Diagnostic Validity of the (13)C-Urea Breath Test in the Gastrectomized Patients: Single Tertiary Center Retrospective Cohort Study
title_short The Diagnostic Validity of the (13)C-Urea Breath Test in the Gastrectomized Patients: Single Tertiary Center Retrospective Cohort Study
title_sort diagnostic validity of the (13)c-urea breath test in the gastrectomized patients: single tertiary center retrospective cohort study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285962/
https://www.ncbi.nlm.nih.gov/pubmed/25574466
http://dx.doi.org/10.15430/JCP.2014.19.4.309
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