Cargando…

Structural polymorphism in the promoter of pfmrp2 confers Plasmodium falciparum tolerance to quinoline drugs

Drug resistance in Plasmodium falciparum remains a challenge for the malaria eradication programmes around the world. With the emergence of artemisinin resistance, the efficacy of the partner drugs in the artemisinin combination therapies (ACT) that include quinoline-based drugs is becoming critical...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mok, Sachel, Liong, Kek-Yee, Lim, Eng-How, Huang, Ximei, Zhu, Lei, Preiser, Peter Rainer, Bozdech, Zbynek
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2014
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286016/ https://www.ncbi.nlm.nih.gov/pubmed/24372851 http://dx.doi.org/10.1111/mmi.12505

Ejemplares similares

Comparative Transcriptional and Genomic Analysis of Plasmodium falciparum Field Isolates
por: Mackinnon, Margaret J., et al.
Publicado: (2009)

Dynamic Epigenetic Regulation of Gene Expression during the Life Cycle of Malaria Parasite Plasmodium falciparum
por: Gupta, Archna P., et al.
Publicado: (2013)

Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription
por: Mok, Sachel, et al.
Publicado: (2011)

Transcriptional variation in the malaria parasite Plasmodium falciparum
por: Rovira-Graells, Núria, et al.
Publicado: (2012)

Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites
por: Rocamora, Frances, et al.
Publicado: (2018)

Localization of the ATP-binding cassette (ABC) transport proteins PfMRP1, PfMRP2, and PfMDR5 at the Plasmodium falciparum plasma membrane
por: Kavishe, Reginald A, et al.
Publicado: (2009)

Gene copy number variation in natural populations of Plasmodium falciparum in Eastern Africa
por: Simam, Joan, et al.
Publicado: (2018)

Plasmodium falciparum Eukaryotic Translation Initiation Factor 3 is Stabilized by Quinazoline-Quinoline Bisubstrate Inhibitors
por: Dobrescu, Irina, et al.
Publicado: (2023)

Design of a variant surface antigen-supplemented microarray chip for whole transcriptome analysis of multiple Plasmodium falciparum cytoadherent strains, and identification of strain-transcendent rif and stevor genes
por: Claessens, Antoine, et al.
Publicado: (2011)

Quantitative protein expression profiling reveals extensive post-transcriptional regulation and post-translational modifications in schizont-stage malaria parasites
por: Foth, Bernardo J, et al.
Publicado: (2008)

Antioxidant defense in Plasmodium falciparum – data mining of the transcriptome
por: Bozdech, Zbynek, et al.
Publicado: (2004)

New insights into the Plasmodium vivax transcriptome using RNA-Seq
por: Zhu, Lei, et al.
Publicado: (2016)

Integrated analysis of the Plasmodium species transcriptome
por: Hoo, Regina, et al.
Publicado: (2016)

Disruption of a Plasmodium falciparum Multidrug Resistance-associated Protein (PfMRP) Alters Its Fitness and Transport of Antimalarial Drugs and Glutathione
por: Raj, Dipak Kumar, et al.
Publicado: (2009)

Data mining of the transcriptome of Plasmodium falciparum: the pentose phosphate pathway and ancillary processes
por: Bozdech, Zbynek, et al.
Publicado: (2005)

Role of Calcium Signaling in the Transcriptional Regulation of the Apicoplast Genome of Plasmodium falciparum
por: Cheemadan, Sabna, et al.
Publicado: (2014)

Analysis of subtelomeric virulence gene families in Plasmodium falciparum by comparative transcriptional profiling
por: Witmer, Kathrin, et al.
Publicado: (2012)

Plasmodium knowlesi gene expression differs in ex vivo compared to in vitro blood-stage cultures
por: Lapp, Stacey A, et al.
Publicado: (2015)

Short tandem repeat polymorphism in the promoter region of cyclophilin 19B drives its transcriptional upregulation and contributes to drug resistance in the malaria parasite Plasmodium falciparum
por: Kucharski, Michal, et al.
Publicado: (2023)

Stochastic expression of invasion genes in Plasmodium falciparum schizonts
por: Tripathi, Jaishree, et al.
Publicado: (2022)

Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance
por: Dogovski, Con, et al.
Publicado: (2015)

The Transcriptome of the Intraerythrocytic Developmental Cycle of Plasmodium falciparum
por: Bozdech, Zbynek, et al.
Publicado: (2003)

Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival
por: Mok, Sachel, et al.
Publicado: (2021)

Antibodies Targeting the PfRH1 Binding Domain Inhibit Invasion of Plasmodium falciparum Merozoites
por: Gao, Xiaohong, et al.
Publicado: (2008)

Comparative whole genome transcriptome analysis of three Plasmodium falciparum strains
por: Llinás, Manuel, et al.
Publicado: (2006)

A Moonlighting Function of Plasmodium falciparum Histone 3, Mono-Methylated at Lysine 9?
por: Luah, Yen-Hoon, et al.
Publicado: (2010)

Mediator Complex of the Malaria Parasite Plasmodium falciparum Associates with Evolutionarily Novel Subunits
por: Iyer, Uthra Balasubramaniyan, et al.
Publicado: (2022)

Transcriptome profiling reveals functional variation in Plasmodium falciparum parasites from controlled human malaria infection studies
por: Hoo, Regina, et al.
Publicado: (2019)

Histone 4 lysine 8 acetylation regulates proliferation and host–pathogen interaction in Plasmodium falciparum
por: Gupta, Archana P., et al.
Publicado: (2017)

Histone Deacetylases Play a Major Role in the Transcriptional Regulation of the Plasmodium falciparum Life Cycle
por: Chaal, Balbir K., et al.
Publicado: (2010)

Expression profiling of the schizont and trophozoite stages of Plasmodium falciparum with a long-oligonucleotide microarray
por: Bozdech, Zbynek, et al.
Publicado: (2003)

Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine
por: Ross, Leila S., et al.
Publicado: (2018)

Comparative Analysis of Plasmodium falciparum Genotyping via SNP Detection, Microsatellite Profiling, and Whole-Genome Sequencing
por: Kanai, Mariko, et al.
Publicado: (2022)

Molecular and physiologic basis of quinoline drug resistance in Plasmodium falciparum malaria
por: Roepe, Paul D
Publicado: (2009)

Selection of long oligonucleotides for gene expression microarrays using weighted rank-sum strategy
por: Hu, Guangan, et al.
Publicado: (2007)

The Plasmodium falciparum STEVOR Multigene Family Mediates Antigenic Variation of the Infected Erythrocyte
por: Niang, Makhtar, et al.
Publicado: (2009)

Sustained Ex Vivo Susceptibility of Plasmodium falciparum to Artemisinin Derivatives but Increasing Tolerance to Artemisinin Combination Therapy Partner Quinolines in The Gambia
por: Amambua-Ngwa, Alfred, et al.
Publicado: (2017)

Correction: The Plasmodium falciparum STEVOR Multigene Family Mediates Antigenic Variation of the Infected Erythrocyte
por: Niang, Makhtar, et al.
Publicado: (2011)

Correction: The Plasmodium falciparum STEVOR Multigene Family Mediates Antigenic Variation of the Infected Erythrocyte
por: Niang, Makhtar, et al.
Publicado: (2009)

Mutant PfCRT Can Mediate Piperaquine Resistance in African Plasmodium falciparum With Reduced Fitness and Increased Susceptibility to Other Antimalarials
por: Wicht, Kathryn J, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_in3ah5lvn71mpousig5ap79su4