Cargando…

Vitamin D Nuclear Receptor Deficiency Promotes Cholestatic Liver Injury by Disruption of Biliary Epithelial Cell Junctions in Mice

Alterations in apical junctional complexes (AJCs) have been reported in genetic or acquired biliary diseases. The vitamin D nuclear receptor (VDR), predominantly expressed in biliary epithelial cells in the liver, has been shown to regulate AJCs. The aim of our study was thus to investigate the role...

Descripción completa

Detalles Bibliográficos
Autores principales:	Firrincieli, Delphine, Zúñiga, Silvia, Rey, Colette, Wendum, Dominique, Lasnier, Elisabeth, Rainteau, Dominique, Braescu, Thomas, Falguières, Thomas, Boissan, Mathieu, Cadoret, Axelle, Housset, Chantal, Chignard, Nicolas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2013
Materias:	Autoimmune, Cholestatic and Biliary Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286017/ https://www.ncbi.nlm.nih.gov/pubmed/23696511 http://dx.doi.org/10.1002/hep.26453

Ejemplares similares

Intrahepatic Cholestasis of Pregnancy Levels of Sulfated Progesterone Metabolites Inhibit Farnesoid X Receptor Resulting in a Cholestatic Phenotype
por: Abu-Hayyeh, Shadi, et al.
Publicado: (2013)

Immunoglobulin G4(+) B‐cell receptor clones distinguish immunoglobulin G 4‐related disease from primary sclerosing cholangitis and biliary/pancreatic malignancies
por: Doorenspleet, Marieke E., et al.
Publicado: (2016)

The SRL peptide of rhesus rotavirus VP4 protein governs cholangiocyte infection and the murine model of biliary atresia
por: Mohanty, Sujit K., et al.
Publicado: (2017)

Human intrahepatic regulatory T cells are functional, require IL‐2 from effector cells for survival, and are susceptible to Fas ligand‐mediated apoptosis
por: Chen, Yung‐Yi, et al.
Publicado: (2016)

Electrostatic Modifications of the Human Leukocyte Antigen-DR P9 Peptide-Binding Pocket and Susceptibility to Primary Sclerosing Cholangitis
por: Hov, Johannes R, et al.
Publicado: (2011)

Pregnane-X-Receptor Controls Hepatic Glucuronidation During Pregnancy and Neonatal Development in Humanized UGT1 Mice
por: Chen, Shujuan, et al.
Publicado: (2012)

Serum Immunoglobulin G4 and Immunoglobulin G1 for Distinguishing Immunoglobulin G4-Associated Cholangitis From Primary Sclerosing Cholangitis
por: Boonstra, Kirsten, et al.
Publicado: (2014)

Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na(+)-taurocholate cotransporting polypeptide knockout mice
por: Slijepcevic, Davor, et al.
Publicado: (2015)

Prognostic and mechanistic potential of progesterone sulfates in intrahepatic cholestasis of pregnancy and pruritus gravidarum
por: Abu‐Hayyeh, Shadi, et al.
Publicado: (2015)

Conjugated Bilirubin Triggers Anemia by Inducing Erythrocyte Death
por: Lang, Elisabeth, et al.
Publicado: (2015)

Association of Severe Intrahepatic Cholestasis of Pregnancy With Adverse Pregnancy Outcomes: A Prospective Population-Based Case-Control Study
por: Geenes, Victoria, et al.
Publicado: (2014)

The toxin biliatresone causes mouse extrahepatic cholangiocyte damage and fibrosis through decreased glutathione and SOX17
por: Waisbourd‐Zinman, Orith, et al.
Publicado: (2016)

Soluble Adenylyl Cyclase Regulates Bile Salt‐Induced Apoptosis in Human Cholangiocytes
por: Chang, Jung‐Chin, et al.
Publicado: (2016)

Engineered fibroblast growth factor 19 reduces liver injury and resolves sclerosing cholangitis in Mdr2‐deficient mice
por: Zhou, Mei, et al.
Publicado: (2016)

Cholestasis‐induced adaptive remodeling of interlobular bile ducts
por: Vartak, Nachiket, et al.
Publicado: (2016)

Defects in myosin VB are associated with a spectrum of previously undiagnosed low γ‐glutamyltransferase cholestasis
por: Qiu, Yi‐Ling, et al.
Publicado: (2017)

Why Doesn’t Primary Biliary Cholangitis Respond to Immunosuppressive Medications?
por: Molinaro, Antonio, et al.
Publicado: (2017)

Bile acids increase steroidogenesis in cholemic mice and induce cortisol secretion in adrenocortical H295R cells via S1PR2, ERK and SF‐1
por: Liu, Lei, et al.
Publicado: (2019)

Are Dominant Strictures in Primary Sclerosing Cholangitis a Risk Factor for Cholangiocarcinoma?
por: Chapman, Roger W, et al.
Publicado: (2017)

The Use of Biologics in Patients with Inflammatory Bowel Disease and Primary Sclerosing Cholangitis
por: Lynch, Kate D., et al.
Publicado: (2019)

Post-transplant biliary complications: advances in pathophysiology, diagnosis, and treatment
por: Fasullo, Matthew, et al.
Publicado: (2022)

Associations between nailfold capillary aberrations and autoantibodies in children and adults with Raynaud’s phenomenon
por: Mueller, Markus, et al.
Publicado: (2023)

Adipokine profile in long-term juvenile dermatomyositis, and associations with adipose tissue distribution and cardiac function: a cross-sectional study
por: Marstein, Henriette Schermacher, et al.
Publicado: (2023)

Diet‐Induced Dysbiosis and Genetic Background Synergize With Cystic Fibrosis Transmembrane Conductance Regulator Deficiency to Promote Cholangiopathy in Mice
por: Debray, Dominique, et al.
Publicado: (2018)

Points to consider for the treatment of immune-mediated inflammatory diseases with Janus kinase inhibitors: a systematic literature research
por: Kerschbaumer, Andreas, et al.
Publicado: (2020)

Antiphospholipid syndrome: state of the art on clinical practice guidelines
por: Limper, Marteen, et al.
Publicado: (2018)

Evolution of multiple sclerosis in France since the beginning of hepatitis B vaccination
por: Le Houézec, Dominique
Publicado: (2014)

Functional Analysis of a Complement Polymorphism (rs17611) Associated with Rheumatoid Arthritis
por: Giles, Joanna L., et al.
Publicado: (2015)

Cancer immunotherapy-induced rheumatic diseases emerge as new clinical entities
por: Cappelli, Laura C, et al.
Publicado: (2016)

Suppression of IRAK1 or IRAK4 Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding–Defective Mutant of ABIN1
por: Nanda, Sambit K., et al.
Publicado: (2016)

Tissue-Resident Exhausted Effector Memory CD8(+) T Cells Accumulate in the Retina during Chronic Experimental Autoimmune Uveoretinitis
por: Boldison, Joanne, et al.
Publicado: (2014)

Characteristics and treatment of new-onset arthritis after checkpoint inhibitor therapy
por: Leipe, Jan, et al.
Publicado: (2018)

Distinct features distinguishing IgG4-related disease from multicentric Castleman’s disease
por: Sasaki, Takanori, et al.
Publicado: (2017)

The Lupus‐Associated Fcγ Receptor IIb–I232T Polymorphism Results in Impairment in the Negative Selection of Low‐Affinity Germinal Center B Cells Via c‐Abl in Mice
por: Jhou, Jyun‐Pei, et al.
Publicado: (2018)

Automated evaluation of ANA under real-life conditions
por: Loock, Clemens Dario, et al.
Publicado: (2017)

Prdm1 Regulates Thymic Epithelial Function To Prevent Autoimmunity
por: Roberts, Natalie A., et al.
Publicado: (2017)

Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice
por: Sood, Shatakshi, et al.
Publicado: (2016)

Tbet or Continued RORγt Expression Is Not Required for Th17-Associated Immunopathology
por: Brucklacher-Waldert, Verena, et al.
Publicado: (2016)

Rheumatic immune-related adverse events of checkpoint therapy for cancer: case series of a new nosological entity
por: Calabrese, C, et al.
Publicado: (2017)

Recognising the spectrum of scleromyositis: HEp-2 ANA patterns allow identification of a novel clinical subset with anti-SMN autoantibodies
por: Landon-Cardinal, Océane, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_k28bhgu1piqkqhfjn519bd0quu