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Role of IL-4Rα during acute schistosomiasis in mice

Schistosomiasis is an important parasitic disease that causes major host morbidity and mortality in endemic areas. Research conducted in mouse models of schistosomiasis has provided great insights and understanding of how host protective immunity is orchestrated and key cellular populations involved...

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Detalles Bibliográficos
Autores principales: Ndlovu, H, Brombacher, F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286023/
https://www.ncbi.nlm.nih.gov/pubmed/24127774
http://dx.doi.org/10.1111/pim.12080
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author Ndlovu, H
Brombacher, F
author_facet Ndlovu, H
Brombacher, F
author_sort Ndlovu, H
collection PubMed
description Schistosomiasis is an important parasitic disease that causes major host morbidity and mortality in endemic areas. Research conducted in mouse models of schistosomiasis has provided great insights and understanding of how host protective immunity is orchestrated and key cellular populations involved in this process. Earlier studies using cytokine-deficient mice demonstrated the importance of IL-4 and IL-10 in mediating host survival during acute schistosomiasis. Subsequent studies employing transgenic mice carrying cell-specific deletion of IL-4Rα generated using the Cre/LoxP recombination system have been instrumental in providing more in-depth understanding of the mechanisms conferring host resistance to Schistosoma mansoni infection. In this review, we will summarize the contributions of IL-4/IL-13-responsive cellular populations in host resistance during acute schistosomiasis and their role in limiting tissue pathology.
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spelling pubmed-42860232015-02-13 Role of IL-4Rα during acute schistosomiasis in mice Ndlovu, H Brombacher, F Parasite Immunol Review Articles Schistosomiasis is an important parasitic disease that causes major host morbidity and mortality in endemic areas. Research conducted in mouse models of schistosomiasis has provided great insights and understanding of how host protective immunity is orchestrated and key cellular populations involved in this process. Earlier studies using cytokine-deficient mice demonstrated the importance of IL-4 and IL-10 in mediating host survival during acute schistosomiasis. Subsequent studies employing transgenic mice carrying cell-specific deletion of IL-4Rα generated using the Cre/LoxP recombination system have been instrumental in providing more in-depth understanding of the mechanisms conferring host resistance to Schistosoma mansoni infection. In this review, we will summarize the contributions of IL-4/IL-13-responsive cellular populations in host resistance during acute schistosomiasis and their role in limiting tissue pathology. BlackWell Publishing Ltd 2014-09 2014-09-08 /pmc/articles/PMC4286023/ /pubmed/24127774 http://dx.doi.org/10.1111/pim.12080 Text en Copyright © 2014 John Wiley & Sons Ltd http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review Articles
Ndlovu, H
Brombacher, F
Role of IL-4Rα during acute schistosomiasis in mice
title Role of IL-4Rα during acute schistosomiasis in mice
title_full Role of IL-4Rα during acute schistosomiasis in mice
title_fullStr Role of IL-4Rα during acute schistosomiasis in mice
title_full_unstemmed Role of IL-4Rα during acute schistosomiasis in mice
title_short Role of IL-4Rα during acute schistosomiasis in mice
title_sort role of il-4rα during acute schistosomiasis in mice
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286023/
https://www.ncbi.nlm.nih.gov/pubmed/24127774
http://dx.doi.org/10.1111/pim.12080
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