Pharmacological properties of JTE-052: a novel potent JAK inhibitor that suppresses various inflammatory responses in vitro and in vivo

OBJECTIVE: To evaluate the pharmacological properties of JTE-052, a novel Janus kinase (JAK) inhibitor. METHODS: The JAK inhibitory activity of JTE-052 was evaluated using recombinant human enzymes. The inhibitory effects on cytokine signaling pathways were evaluated using primary human inflammatory...

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Detalles Bibliográficos
Autores principales: Tanimoto, Atsuo, Ogawa, Yoshihiro, Oki, Chika, Kimoto, Yukari, Nozawa, Keisuke, Amano, Wataru, Noji, Satoru, Shiozaki, Makoto, Matsuo, Akira, Shinozaki, Yuichi, Matsushita, Mutsuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Basel 2014
Materias:
Original Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286029/
https://www.ncbi.nlm.nih.gov/pubmed/25387665
http://dx.doi.org/10.1007/s00011-014-0782-9

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