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Regulation of T-cell Tolerance by Lymphatic Endothelial Cells

Lymphatic endothelial cells are most often thought of as structural cells that form the lymphatic vasculature, which transports fluid out of peripheral tissues and transports antigens and antigen presenting cells to lymph nodes. Recently, it has been shown that lymphatic endothelial cells also dynam...

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Detalles Bibliográficos
Autores principales: Rouhani, Sherin J., Eccles, Jacob D., Tewalt, Eric F., Engelhard, Victor H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286360/
https://www.ncbi.nlm.nih.gov/pubmed/25580369
http://dx.doi.org/10.4172/2155-9899.1000242
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author Rouhani, Sherin J.
Eccles, Jacob D.
Tewalt, Eric F.
Engelhard, Victor H.
author_facet Rouhani, Sherin J.
Eccles, Jacob D.
Tewalt, Eric F.
Engelhard, Victor H.
author_sort Rouhani, Sherin J.
collection PubMed
description Lymphatic endothelial cells are most often thought of as structural cells that form the lymphatic vasculature, which transports fluid out of peripheral tissues and transports antigens and antigen presenting cells to lymph nodes. Recently, it has been shown that lymphatic endothelial cells also dynamically respond to and influence the immune response in several ways. Here, we describe how lymphatic endothelial cells induce peripheral T-cell tolerance and how this relates to tolerance induced by other types of antigen presenting cells. Furthermore, the ability of lymphatic endothelial cells to alter immune responses under steady-state or inflammatory conditions is explored, and the therapeutic potential of bypassing lymphatic endothelial cell-induced tolerance to enhance cancer immunotherapy is discussed.
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spelling pubmed-42863602015-01-07 Regulation of T-cell Tolerance by Lymphatic Endothelial Cells Rouhani, Sherin J. Eccles, Jacob D. Tewalt, Eric F. Engelhard, Victor H. J Clin Cell Immunol Article Lymphatic endothelial cells are most often thought of as structural cells that form the lymphatic vasculature, which transports fluid out of peripheral tissues and transports antigens and antigen presenting cells to lymph nodes. Recently, it has been shown that lymphatic endothelial cells also dynamically respond to and influence the immune response in several ways. Here, we describe how lymphatic endothelial cells induce peripheral T-cell tolerance and how this relates to tolerance induced by other types of antigen presenting cells. Furthermore, the ability of lymphatic endothelial cells to alter immune responses under steady-state or inflammatory conditions is explored, and the therapeutic potential of bypassing lymphatic endothelial cell-induced tolerance to enhance cancer immunotherapy is discussed. 2014-07-31 2014 /pmc/articles/PMC4286360/ /pubmed/25580369 http://dx.doi.org/10.4172/2155-9899.1000242 Text en Copyright: © 2014 Rouhani SJ, et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Rouhani, Sherin J.
Eccles, Jacob D.
Tewalt, Eric F.
Engelhard, Victor H.
Regulation of T-cell Tolerance by Lymphatic Endothelial Cells
title Regulation of T-cell Tolerance by Lymphatic Endothelial Cells
title_full Regulation of T-cell Tolerance by Lymphatic Endothelial Cells
title_fullStr Regulation of T-cell Tolerance by Lymphatic Endothelial Cells
title_full_unstemmed Regulation of T-cell Tolerance by Lymphatic Endothelial Cells
title_short Regulation of T-cell Tolerance by Lymphatic Endothelial Cells
title_sort regulation of t-cell tolerance by lymphatic endothelial cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286360/
https://www.ncbi.nlm.nih.gov/pubmed/25580369
http://dx.doi.org/10.4172/2155-9899.1000242
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