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THE AAA3 DOMAIN OF CYTOPLASMIC DYNEIN ACTS AS A SWITCH TO FACILITATE MICROTUBULE RELEASE

Cytoplasmic dynein is an AAA+ motor responsible for intracellular cargo transport and force generation along microtubules (MTs). Unlike kinesin and myosin, dynein contains multiple ATPase subunits, with AAA1 serving as the primary catalytic site. ATPase activity at AAA3 is also essential for robust...

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Detalles Bibliográficos
Autores principales:	Dewitt, Mark A., Cypranowska, Caroline A., Cleary, Frank B., Belyy, Vladislav, Yildiz, Ahmet
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286497/ https://www.ncbi.nlm.nih.gov/pubmed/25486306 http://dx.doi.org/10.1038/nsmb.2930

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