Allelic Variation, Aneuploidy, and Nongenetic Mechanisms Suppress a Monogenic Trait in Yeast

Clinically relevant features of monogenic diseases, including severity of symptoms and age of onset, can vary widely in response to environmental differences as well as to the presence of genetic modifiers affecting the trait’s penetrance and expressivity. While a better understanding of modifier lo...

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Detalles Bibliográficos
Autores principales: Sirr, Amy, Cromie, Gareth A., Jeffery, Eric W., Gilbert, Teresa L., Ludlow, Catherine L., Scott, Adrian C., Dudley, Aimée M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2015
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286688/
https://www.ncbi.nlm.nih.gov/pubmed/25398792
http://dx.doi.org/10.1534/genetics.114.170563

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286688/
https://www.ncbi.nlm.nih.gov/pubmed/25398792
http://dx.doi.org/10.1534/genetics.114.170563

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