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Are Women With Polycystic Ovarian Syndrome at a High Risk of Non-Alcoholic Fatty Liver Disease; A Meta-Analysis

CONTEXT: Insulin resistance is a hallmark of metabolic syndrome (MS). It has been proposed that both polycystic ovarian syndrome (PCOS) and nonalcoholic fatty liver disease (NAFLD) are correlated with Insulin resistance. Therefore, PCOS and NAFLD can be attributed with insulin resistance and therefo...

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Autores principales: Ramezani-Binabaj, Mahdi, Motalebi, Mohsen, Karimi-sari, Hamidreza, Rezaee-Zavareh, Mohammad Saeid, Alavian, Seyed Moayed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286712/
https://www.ncbi.nlm.nih.gov/pubmed/25598791
http://dx.doi.org/10.5812/hepatmon.23235
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author Ramezani-Binabaj, Mahdi
Motalebi, Mohsen
Karimi-sari, Hamidreza
Rezaee-Zavareh, Mohammad Saeid
Alavian, Seyed Moayed
author_facet Ramezani-Binabaj, Mahdi
Motalebi, Mohsen
Karimi-sari, Hamidreza
Rezaee-Zavareh, Mohammad Saeid
Alavian, Seyed Moayed
author_sort Ramezani-Binabaj, Mahdi
collection PubMed
description CONTEXT: Insulin resistance is a hallmark of metabolic syndrome (MS). It has been proposed that both polycystic ovarian syndrome (PCOS) and nonalcoholic fatty liver disease (NAFLD) are correlated with Insulin resistance. Therefore, PCOS and NAFLD can be attributed with insulin resistance and therefore MS. The aim of this meta-analysis was to determine whether PCOS patients are at a high risk of NAFLD. EVIDENCE ACQUISITION: Google scholar, Scopus, ISI Web of Science, Embase, MEDLINE, and some Iranian databases such as scientific information database (SID), IranMedex, and MagIran were searched to identify relevant studies. We included all papers regardless of their language from January 1985 to June 2013. By using data on prevalence of NAFLD in patients with and without PCOS, odds ratio (OR) with 95% confidence intervals (CIs) were calculated in each study. Chi-squared test was used to assess heterogeneity between studies. RESULTS: We finally included seven eligible studies. According to chi-squared test, there was a significant heterogeneity (73.6%) between studies (P = 0.001). NAFLD prevalence was significantly higher in patients with PCOS compared to healthy control, with an overall OR of 3.93 (95% CI: 2.17, 7.11).There was no significant publication bias based on Begg's and Egger's tests. CONCLUSIONS: According to the results of this meta-analysis, there was a high risk of NAFLD in women with PCOS. We suggest evaluating patients with PCOS regarding NAFLD.
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spelling pubmed-42867122015-01-16 Are Women With Polycystic Ovarian Syndrome at a High Risk of Non-Alcoholic Fatty Liver Disease; A Meta-Analysis Ramezani-Binabaj, Mahdi Motalebi, Mohsen Karimi-sari, Hamidreza Rezaee-Zavareh, Mohammad Saeid Alavian, Seyed Moayed Hepat Mon Review Article CONTEXT: Insulin resistance is a hallmark of metabolic syndrome (MS). It has been proposed that both polycystic ovarian syndrome (PCOS) and nonalcoholic fatty liver disease (NAFLD) are correlated with Insulin resistance. Therefore, PCOS and NAFLD can be attributed with insulin resistance and therefore MS. The aim of this meta-analysis was to determine whether PCOS patients are at a high risk of NAFLD. EVIDENCE ACQUISITION: Google scholar, Scopus, ISI Web of Science, Embase, MEDLINE, and some Iranian databases such as scientific information database (SID), IranMedex, and MagIran were searched to identify relevant studies. We included all papers regardless of their language from January 1985 to June 2013. By using data on prevalence of NAFLD in patients with and without PCOS, odds ratio (OR) with 95% confidence intervals (CIs) were calculated in each study. Chi-squared test was used to assess heterogeneity between studies. RESULTS: We finally included seven eligible studies. According to chi-squared test, there was a significant heterogeneity (73.6%) between studies (P = 0.001). NAFLD prevalence was significantly higher in patients with PCOS compared to healthy control, with an overall OR of 3.93 (95% CI: 2.17, 7.11).There was no significant publication bias based on Begg's and Egger's tests. CONCLUSIONS: According to the results of this meta-analysis, there was a high risk of NAFLD in women with PCOS. We suggest evaluating patients with PCOS regarding NAFLD. Kowsar 2014-11-01 /pmc/articles/PMC4286712/ /pubmed/25598791 http://dx.doi.org/10.5812/hepatmon.23235 Text en Copyright © 2014, Hepatitis Monthly. http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Review Article
Ramezani-Binabaj, Mahdi
Motalebi, Mohsen
Karimi-sari, Hamidreza
Rezaee-Zavareh, Mohammad Saeid
Alavian, Seyed Moayed
Are Women With Polycystic Ovarian Syndrome at a High Risk of Non-Alcoholic Fatty Liver Disease; A Meta-Analysis
title Are Women With Polycystic Ovarian Syndrome at a High Risk of Non-Alcoholic Fatty Liver Disease; A Meta-Analysis
title_full Are Women With Polycystic Ovarian Syndrome at a High Risk of Non-Alcoholic Fatty Liver Disease; A Meta-Analysis
title_fullStr Are Women With Polycystic Ovarian Syndrome at a High Risk of Non-Alcoholic Fatty Liver Disease; A Meta-Analysis
title_full_unstemmed Are Women With Polycystic Ovarian Syndrome at a High Risk of Non-Alcoholic Fatty Liver Disease; A Meta-Analysis
title_short Are Women With Polycystic Ovarian Syndrome at a High Risk of Non-Alcoholic Fatty Liver Disease; A Meta-Analysis
title_sort are women with polycystic ovarian syndrome at a high risk of non-alcoholic fatty liver disease; a meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286712/
https://www.ncbi.nlm.nih.gov/pubmed/25598791
http://dx.doi.org/10.5812/hepatmon.23235
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