Palladium-Catalyzed C8-Selective C–H Arylation of Quinoline N-Oxides: Insights into the Electronic, Steric, and Solvation Effects on the Site Selectivity by Mechanistic and DFT Computational Studies

[Image: see text] We report herein a palladium-catalyzed C–H arylation of quinoline N-oxides that proceeds with high selectivity in favor of the C8 isomer. This site selectivity is unusual for palladium, since all of the hitherto described methods of palladium-catalyzed C–H functionalization of quin...

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Autores principales: Stephens, David E., Lakey-Beitia, Johant, Atesin, Abdurrahman C., Ateşin, Tülay A., Chavez, Gabriel, Arman, Hadi D., Larionov, Oleg V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286811/
https://www.ncbi.nlm.nih.gov/pubmed/25580364
http://dx.doi.org/10.1021/cs501813v

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