Enantiomeric Separation of Monosubstituted Tryptophan Derivatives and Metabolites by HPLC with a Cinchona Alkaloid-Based Zwitterionic Chiral Stationary Phase and Its Application to the Evaluation of the Optical Purity of Synthesized 6-Chloro-l-Tryptophan

6-Chlorotryptophan possesses unique bioactivity and can be used as a precursor for several bioactive compounds in medicinal chemistry. It was enantioselectively synthesized by condensing 6-chloroindole with racemic N-acetylserine, followed by enzymatic hydrolysis with l-aminoacylase (EC 3.5.1.14). T...

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Detalles Bibliográficos
Autores principales: Fukushima, Takeshi, Sugiura, Anna, Furuta, Ippei, Iwasa, Sumiko, Iizuka, Hideaki, Ichiba, Hideaki, Onozato, Mayu, Hikawa, Hidemasa, Yokoyama, Yuusaku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287053/
https://www.ncbi.nlm.nih.gov/pubmed/25624766
http://dx.doi.org/10.4137/IJTR.S20381

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