The relationship between Graves’ ophthalmopathy and dry eye syndrome

BACKGROUND: A complex relationship between Graves’ ophthalmopathy (GO) and dry eye syndrome exists. New research brings more insight into the association between these two diseases. METHODS: A review of the literature was conducted using the query terms “Graves’ Ophthalmopathy”, “Thyroid Eye Disease...

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Autores principales: Selter, Jessica H, Gire, Anisa I, Sikder, Shameema
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287254/
https://www.ncbi.nlm.nih.gov/pubmed/25584018
http://dx.doi.org/10.2147/OPTH.S76583
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author Selter, Jessica H
Gire, Anisa I
Sikder, Shameema
author_facet Selter, Jessica H
Gire, Anisa I
Sikder, Shameema
author_sort Selter, Jessica H
collection PubMed
description BACKGROUND: A complex relationship between Graves’ ophthalmopathy (GO) and dry eye syndrome exists. New research brings more insight into the association between these two diseases. METHODS: A review of the literature was conducted using the query terms “Graves’ Ophthalmopathy”, “Thyroid Eye Disease”, and “Dry Eye” in MedLine (PubMed) and Scopus. A total of 55 papers were reviewed. Case reports were excluded. CONCLUSION: This review paper shows the close relationship between dry eye syndrome and GO. The underlying mechanisms behind their association suggest mechanical impairment of orbital muscles and immune-mediated lacrimal gland dysfunction as the causes of dry eye in GO patients. However, there are a variety of treatment options available for patients with GO with signs of dry eye, which help combat this issue.
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spelling pubmed-42872542015-01-12 The relationship between Graves’ ophthalmopathy and dry eye syndrome Selter, Jessica H Gire, Anisa I Sikder, Shameema Clin Ophthalmol Review BACKGROUND: A complex relationship between Graves’ ophthalmopathy (GO) and dry eye syndrome exists. New research brings more insight into the association between these two diseases. METHODS: A review of the literature was conducted using the query terms “Graves’ Ophthalmopathy”, “Thyroid Eye Disease”, and “Dry Eye” in MedLine (PubMed) and Scopus. A total of 55 papers were reviewed. Case reports were excluded. CONCLUSION: This review paper shows the close relationship between dry eye syndrome and GO. The underlying mechanisms behind their association suggest mechanical impairment of orbital muscles and immune-mediated lacrimal gland dysfunction as the causes of dry eye in GO patients. However, there are a variety of treatment options available for patients with GO with signs of dry eye, which help combat this issue. Dove Medical Press 2014-12-31 /pmc/articles/PMC4287254/ /pubmed/25584018 http://dx.doi.org/10.2147/OPTH.S76583 Text en © 2015 Selter et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Selter, Jessica H
Gire, Anisa I
Sikder, Shameema
The relationship between Graves’ ophthalmopathy and dry eye syndrome
title The relationship between Graves’ ophthalmopathy and dry eye syndrome
title_full The relationship between Graves’ ophthalmopathy and dry eye syndrome
title_fullStr The relationship between Graves’ ophthalmopathy and dry eye syndrome
title_full_unstemmed The relationship between Graves’ ophthalmopathy and dry eye syndrome
title_short The relationship between Graves’ ophthalmopathy and dry eye syndrome
title_sort relationship between graves’ ophthalmopathy and dry eye syndrome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287254/
https://www.ncbi.nlm.nih.gov/pubmed/25584018
http://dx.doi.org/10.2147/OPTH.S76583
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