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Identification of Constrained Cancer Driver Genes Based on Mutation Timing
Cancer drivers are genomic alterations that provide cells containing them with a selective advantage over their local competitors, whereas neutral passengers do not change the somatic fitness of cells. Cancer-driving mutations are usually discriminated from passenger mutations by their higher degree...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287396/ https://www.ncbi.nlm.nih.gov/pubmed/25569148 http://dx.doi.org/10.1371/journal.pcbi.1004027 |