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Interactions of Chromatin Context, Binding Site Sequence Content, and Sequence Evolution in Stress-Induced p53 Occupancy and Transactivation

Cellular stresses activate the tumor suppressor p53 protein leading to selective binding to DNA response elements (REs) and gene transactivation from a large pool of potential p53 REs (p53REs). To elucidate how p53RE sequences and local chromatin context interact to affect p53 binding and gene trans...

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Detalles Bibliográficos
Autores principales:	Su, Dan, Wang, Xuting, Campbell, Michelle R., Song, Lingyun, Safi, Alexias, Crawford, Gregory E., Bell, Douglas A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287438/ https://www.ncbi.nlm.nih.gov/pubmed/25569532 http://dx.doi.org/10.1371/journal.pgen.1004885

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