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Functional Interplay between the 53BP1-Ortholog Rad9 and the Mre11 Complex Regulates Resection, End-Tethering and Repair of a Double-Strand Break

The Mre11-Rad50-Xrs2 nuclease complex, together with Sae2, initiates the 5′-to-3′ resection of Double-Strand DNA Breaks (DSBs). Extended 3′ single stranded DNA filaments can be exposed from a DSB through the redundant activities of the Exo1 nuclease and the Dna2 nuclease with the Sgs1 helicase. In t...

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Detalles Bibliográficos
Autores principales:	Ferrari, Matteo, Dibitetto, Diego, De Gregorio, Giuseppe, Eapen, Vinay V., Rawal, Chetan C., Lazzaro, Federico, Tsabar, Michael, Marini, Federica, Haber, James E., Pellicioli, Achille
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287487/ https://www.ncbi.nlm.nih.gov/pubmed/25569305 http://dx.doi.org/10.1371/journal.pgen.1004928

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