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Protective Efficacy of Centralized and Polyvalent Envelope Immunogens in an Attenuated Equine Lentivirus Vaccine

Lentiviral Envelope (Env) antigenic variation and related immune evasion present major hurdles to effective vaccine development. Centralized Env immunogens that minimize the genetic distance between vaccine proteins and circulating viral isolates are an area of increasing study in HIV vaccinology. T...

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Detalles Bibliográficos
Autores principales: Craigo, Jodi K., Ezzelarab, Corin, Cook, Sheila J., Liu, Chong, Horohov, David, Issel, Charles J., Montelaro, Ronald C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287611/
https://www.ncbi.nlm.nih.gov/pubmed/25569288
http://dx.doi.org/10.1371/journal.ppat.1004610