MCT-1 expression and PTEN deficiency synergistically promote neoplastic multinucleation through the Src/p190B signaling activation

Multinucleation is associated with malignant neoplasms; however, the molecular mechanism underlying the nuclear abnormality remains unclear. Loss or mutation of PTEN promotes the development of malignant tumors. We now demonstrate that increased expression of the oncogene MCT-1 (multiple copies in T...

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Detalles Bibliográficos
Autores principales: Wu, M-H, Chen, Y-A, Chen, H-H, Chang, K-W, Chang, I-S, Wang, L-H, Hsu, H-L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287651/
https://www.ncbi.nlm.nih.gov/pubmed/24858043
http://dx.doi.org/10.1038/onc.2014.125

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