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Evolving targets for lipid-modifying therapy

The pathogenesis and progression of atherosclerosis are integrally connected to the concentration and function of lipoproteins in various classes. This review examines existing and emerging approaches to modify low-density lipoprotein and lipoprotein (a), triglyceride-rich lipoproteins, and high-den...

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Detalles Bibliográficos
Autores principales: Do, Rose Q, Nicholls, Stephen J, Schwartz, Gregory G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287928/
https://www.ncbi.nlm.nih.gov/pubmed/25172365
http://dx.doi.org/10.15252/emmm.201404000
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author Do, Rose Q
Nicholls, Stephen J
Schwartz, Gregory G
author_facet Do, Rose Q
Nicholls, Stephen J
Schwartz, Gregory G
author_sort Do, Rose Q
collection PubMed
description The pathogenesis and progression of atherosclerosis are integrally connected to the concentration and function of lipoproteins in various classes. This review examines existing and emerging approaches to modify low-density lipoprotein and lipoprotein (a), triglyceride-rich lipoproteins, and high-density lipoproteins, emphasizing approaches that have progressed to clinical evaluation. Targeting of nuclear receptors and phospholipases is also discussed.
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spelling pubmed-42879282015-01-12 Evolving targets for lipid-modifying therapy Do, Rose Q Nicholls, Stephen J Schwartz, Gregory G EMBO Mol Med Review The pathogenesis and progression of atherosclerosis are integrally connected to the concentration and function of lipoproteins in various classes. This review examines existing and emerging approaches to modify low-density lipoprotein and lipoprotein (a), triglyceride-rich lipoproteins, and high-density lipoproteins, emphasizing approaches that have progressed to clinical evaluation. Targeting of nuclear receptors and phospholipases is also discussed. BlackWell Publishing Ltd 2014-10 2014-08-29 /pmc/articles/PMC4287928/ /pubmed/25172365 http://dx.doi.org/10.15252/emmm.201404000 Text en © 2014 The Authors. Published under the terms of the CC BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution 4.0 License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Do, Rose Q
Nicholls, Stephen J
Schwartz, Gregory G
Evolving targets for lipid-modifying therapy
title Evolving targets for lipid-modifying therapy
title_full Evolving targets for lipid-modifying therapy
title_fullStr Evolving targets for lipid-modifying therapy
title_full_unstemmed Evolving targets for lipid-modifying therapy
title_short Evolving targets for lipid-modifying therapy
title_sort evolving targets for lipid-modifying therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287928/
https://www.ncbi.nlm.nih.gov/pubmed/25172365
http://dx.doi.org/10.15252/emmm.201404000
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