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Evolving targets for lipid-modifying therapy
The pathogenesis and progression of atherosclerosis are integrally connected to the concentration and function of lipoproteins in various classes. This review examines existing and emerging approaches to modify low-density lipoprotein and lipoprotein (a), triglyceride-rich lipoproteins, and high-den...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BlackWell Publishing Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287928/ https://www.ncbi.nlm.nih.gov/pubmed/25172365 http://dx.doi.org/10.15252/emmm.201404000 |
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author | Do, Rose Q Nicholls, Stephen J Schwartz, Gregory G |
author_facet | Do, Rose Q Nicholls, Stephen J Schwartz, Gregory G |
author_sort | Do, Rose Q |
collection | PubMed |
description | The pathogenesis and progression of atherosclerosis are integrally connected to the concentration and function of lipoproteins in various classes. This review examines existing and emerging approaches to modify low-density lipoprotein and lipoprotein (a), triglyceride-rich lipoproteins, and high-density lipoproteins, emphasizing approaches that have progressed to clinical evaluation. Targeting of nuclear receptors and phospholipases is also discussed. |
format | Online Article Text |
id | pubmed-4287928 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BlackWell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-42879282015-01-12 Evolving targets for lipid-modifying therapy Do, Rose Q Nicholls, Stephen J Schwartz, Gregory G EMBO Mol Med Review The pathogenesis and progression of atherosclerosis are integrally connected to the concentration and function of lipoproteins in various classes. This review examines existing and emerging approaches to modify low-density lipoprotein and lipoprotein (a), triglyceride-rich lipoproteins, and high-density lipoproteins, emphasizing approaches that have progressed to clinical evaluation. Targeting of nuclear receptors and phospholipases is also discussed. BlackWell Publishing Ltd 2014-10 2014-08-29 /pmc/articles/PMC4287928/ /pubmed/25172365 http://dx.doi.org/10.15252/emmm.201404000 Text en © 2014 The Authors. Published under the terms of the CC BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution 4.0 License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Do, Rose Q Nicholls, Stephen J Schwartz, Gregory G Evolving targets for lipid-modifying therapy |
title | Evolving targets for lipid-modifying therapy |
title_full | Evolving targets for lipid-modifying therapy |
title_fullStr | Evolving targets for lipid-modifying therapy |
title_full_unstemmed | Evolving targets for lipid-modifying therapy |
title_short | Evolving targets for lipid-modifying therapy |
title_sort | evolving targets for lipid-modifying therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287928/ https://www.ncbi.nlm.nih.gov/pubmed/25172365 http://dx.doi.org/10.15252/emmm.201404000 |
work_keys_str_mv | AT doroseq evolvingtargetsforlipidmodifyingtherapy AT nichollsstephenj evolvingtargetsforlipidmodifyingtherapy AT schwartzgregoryg evolvingtargetsforlipidmodifyingtherapy |