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Insulin-like growth factor 2 reverses memory and synaptic deficits in APP transgenic mice

Insulin-like growth factor 2 (IGF2) was recently found to play a critical role in memory consolidation in rats and mice, and hippocampal or systemic administration of recombinant IGF2 enhances memory. Here, using a gene therapy-based approach with adeno-associated virus (AAV), we show that IGF2 over...

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Detalles Bibliográficos
Autores principales:	Pascual-Lucas, Maria, Viana da Silva, Silvia, Di Scala, Marianna, Garcia-Barroso, Carolina, González-Aseguinolaza, Gloria, Mulle, Christophe, Alberini, Cristina M, Cuadrado-Tejedor, Mar, Garcia-Osta, Ana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2014
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287930/ https://www.ncbi.nlm.nih.gov/pubmed/25100745 http://dx.doi.org/10.15252/emmm.201404228

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