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Tipping the MYC–MIZ1 balance: targeting the HUWE1 ubiquitin ligase selectively blocks MYC-activated genes

MYC family oncoproteins (MYC, N-MYC and L-MYC) function as basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factors that are activated (i.e., overexpressed) in well over half of all human malignancies (Boxer & Dang, 2001; Beroukhim et al, 2010). In this issue of EMBO Molecular Medi...

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Detalles Bibliográficos
Autores principales:	Schaub, Franz X, Cleveland, John L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2014
Materias:	Closeups
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287968/ https://www.ncbi.nlm.nih.gov/pubmed/25368331 http://dx.doi.org/10.15252/emmm.201404735

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