Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K

The tumor suppressors Pten and p53 are frequently lost in breast cancer, yet the consequences of their combined inactivation are poorly understood. Here, we show that mammary-specific deletion of Pten via WAP-Cre, which targets alveolar progenitors, induced tumors with shortened latency compared to...

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Detalles Bibliográficos
Autores principales: Liu, Jeff C, Voisin, Veronique, Wang, Sharon, Wang, Dong-Yu, Jones, Robert A, Datti, Alessandro, Uehling, David, Al-awar, Rima, Egan, Sean E, Bader, Gary D, Tsao, Ming, Mak, Tak W, Zacksenhaus, Eldad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287974/
https://www.ncbi.nlm.nih.gov/pubmed/25330770
http://dx.doi.org/10.15252/emmm.201404402

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287974/
https://www.ncbi.nlm.nih.gov/pubmed/25330770
http://dx.doi.org/10.15252/emmm.201404402

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