Deletion of the von Hippel–Lindau gene causes sympathoadrenal cell death and impairs chemoreceptor-mediated adaptation to hypoxia

Mutations of the von Hippel–Lindau (VHL) gene are associated with pheochromocytomas and paragangliomas, but the role of VHL in sympathoadrenal homeostasis is unknown. We generated mice lacking Vhl in catecholaminergic cells. They exhibited atrophy of the carotid body (CB), adrenal medulla, and sympa...

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Detalles Bibliográficos
Autores principales: Macías, David, Fernández-Agüera, Mary Carmen, Bonilla-Henao, Victoria, López-Barneo, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287976/
https://www.ncbi.nlm.nih.gov/pubmed/25385837
http://dx.doi.org/10.15252/emmm.201404153

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