A genome-wide association study of marginal zone lymphoma shows association to the HLA region

Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(−15)) and HLA-B (rs2922994, P=2.43 × 10(−9))...

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Detalles Bibliográficos
Autores principales: Vijai, Joseph, Wang, Zhaoming, Berndt, Sonja I., Skibola, Christine F., Slager, Susan L., de Sanjose, Silvia, Melbye, Mads, Glimelius, Bengt, Bracci, Paige M., Conde, Lucia, Birmann, Brenda M., Wang, Sophia S., Brooks-Wilson, Angela R., Lan, Qing, de Bakker, Paul I. W., Vermeulen, Roel C. H., Portlock, Carol, Ansell, Stephen M., Link, Brian K., Riby, Jacques, North, Kari E., Gu, Jian, Hjalgrim, Henrik, Cozen, Wendy, Becker, Nikolaus, Teras, Lauren R., Spinelli, John J., Turner, Jenny, Zhang, Yawei, Purdue, Mark P., Giles, Graham G., Kelly, Rachel S., Zeleniuch-Jacquotte, Anne, Ennas, Maria Grazia, Monnereau, Alain, Bertrand, Kimberly A., Albanes, Demetrius, Lightfoot, Tracy, Yeager, Meredith, Chung, Charles C., Burdett, Laurie, Hutchinson, Amy, Lawrence, Charles, Montalvan, Rebecca, Liang, Liming, Huang, Jinyan, Ma, Baoshan, Villano, Danylo J., Maria, Ann, Corines, Marina, Thomas, Tinu, Novak, Anne J., Dogan, Ahmet, Liebow, Mark, Thompson, Carrie A., Witzig, Thomas E., Habermann, Thomas M., Weiner, George J., Smith, Martyn T., Holly, Elizabeth A., Jackson, Rebecca D., Tinker, Lesley F., Ye, Yuanqing, Adami, Hans-Olov, Smedby, Karin E., De Roos, Anneclaire J., Hartge, Patricia, Morton, Lindsay M., Severson, Richard K., Benavente, Yolanda, Boffetta, Paolo, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, McKay, James, Staines, Anthony, Diver, W. Ryan, Vajdic, Claire M., Armstrong, Bruce K., Kricker, Anne, Zheng, Tongzhang, Holford, Theodore R., Severi, Gianluca, Vineis, Paolo, Ferri, Giovanni M., Ricco, Rosalia, Miligi, Lucia, Clavel, Jacqueline, Giovannucci, Edward, Kraft, Peter, Virtamo, Jarmo, Smith, Alex, Kane, Eleanor, Roman, Eve, Chiu, Brian C. H., Fraumeni, Joseph F., Wu, Xifeng, Cerhan, James R., Offit, Kenneth, Chanock, Stephen J., Rothman, Nathaniel, Nieters, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287989/
https://www.ncbi.nlm.nih.gov/pubmed/25569183
http://dx.doi.org/10.1038/ncomms6751
Descripción
Sumario:Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(−15)) and HLA-B (rs2922994, P=2.43 × 10(−9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.

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