Identification of SMG6 cleavage sites and a preferred RNA cleavage motif by global analysis of endogenous NMD targets in human cells

In metazoans, cleavage by the endoribonuclease SMG6 is often the first degradative event in non-sense-mediated mRNA decay (NMD). However, the exact sites of SMG6 cleavage have yet to be determined for any endogenous targets, and most evidence as to the identity of SMG6 substrates is indirect. Here,...

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Detalles Bibliográficos
Autores principales: Schmidt, Skye A., Foley, Patricia L., Jeong, Dong-Hoon, Rymarquis, Linda A., Doyle, Francis, Tenenbaum, Scott A., Belasco, Joel G., Green, Pamela J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288159/
https://www.ncbi.nlm.nih.gov/pubmed/25429978
http://dx.doi.org/10.1093/nar/gku1258

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