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ARTD1-induced poly-ADP-ribose formation enhances PPARγ ligand binding and co-factor exchange

PPARγ-dependent gene expression during adipogenesis is facilitated by ADP-ribosyltransferase D-type 1 (ARTD1; PARP1)-catalyzed poly-ADP-ribose (PAR) formation. Adipogenesis is accompanied by a dynamic modulation of the chromatin landscape at PPARγ target genes by ligand-dependent co-factor exchange....

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Detalles Bibliográficos
Autores principales:	Lehmann, Mareike, Pirinen, Eija, Mirsaidi, Ali, Kunze, Friedrich A., Richards, Peter J., Auwerx, Johan, Hottiger, Michael O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288160/ https://www.ncbi.nlm.nih.gov/pubmed/25452336 http://dx.doi.org/10.1093/nar/gku1260

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