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Tracing the molecular basis of transcriptional dynamics in noisy data by using an experiment-based mathematical model
Changes in transcription factor levels, epigenetic status, splicing kinetics and mRNA degradation can each contribute to changes in the mRNA dynamics of a gene. We present a novel method to identify which of these processes is changed in cells in response to external signals or as a result of a dise...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288170/ https://www.ncbi.nlm.nih.gov/pubmed/25477385 http://dx.doi.org/10.1093/nar/gku1272 |