The high mobility group A2 protein epigenetically silences the Cdh1 gene during epithelial-to-mesenchymal transition

The loss of the tumour suppressor E-cadherin (Cdh1) is a key event during tumourigenesis and epithelial–mesenchymal transition (EMT). Transforming growth factor-β (TGFβ) triggers EMT by inducing the expression of non-histone chromatin protein High Mobility Group A2 (HMGA2). We have previously shown...

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Detalles Bibliográficos
Autores principales: Tan, E-Jean, Kahata, Kaoru, Idås, Oskar, Thuault, Sylvie, Heldin, Carl-Henrik, Moustakas, Aristidis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288184/
https://www.ncbi.nlm.nih.gov/pubmed/25492890
http://dx.doi.org/10.1093/nar/gku1293

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