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LKB1 preserves genome integrity by stimulating BRCA1 expression

Serine/threonine kinase 11 (STK11, also known as LKB1) functions as a tumor suppressor in many human cancers. However, paradoxically loss of LKB1 in mouse embryonic fibroblast results in resistance to oncogene-induced transformation. Therefore, it is unclear why loss of LKB1 leads to increased predi...

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Detalles Bibliográficos
Autores principales: Gupta, Romi, Liu, Alex. Y., Glazer, Peter M., Wajapeyee, Narendra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288185/
https://www.ncbi.nlm.nih.gov/pubmed/25488815
http://dx.doi.org/10.1093/nar/gku1294

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