Rescue of splicing-mediated intron loss maximizes expression in lentiviral vectors containing the human ubiquitin C promoter

Lentiviral vectors almost universally use heterologous internal promoters to express transgenes. One of the most commonly used promoter fragments is a 1.2-kb sequence from the human ubiquitin C (UBC) gene, encompassing the promoter, some enhancers, first exon, first intron and a small part of the se...

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Detalles Bibliográficos
Autores principales: Cooper, Aaron R., Lill, Georgia R., Gschweng, Eric H., Kohn, Donald B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Synthetic Biology and Bioengineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288199/
https://www.ncbi.nlm.nih.gov/pubmed/25520191
http://dx.doi.org/10.1093/nar/gku1312

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288199/
https://www.ncbi.nlm.nih.gov/pubmed/25520191
http://dx.doi.org/10.1093/nar/gku1312

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