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Repurposing endogenous type I CRISPR-Cas systems for programmable gene repression

CRISPR-Cas systems have shown tremendous promise as heterologous tools for genome editing and transcriptional regulation. Because these RNA-directed immune systems are found in most prokaryotes, an opportunity exists to harness the endogenous systems as convenient tools in these organisms. Here, we...

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Detalles Bibliográficos
Autores principales:	Luo, Michelle L., Mullis, Adam S., Leenay, Ryan T., Beisel, Chase L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Synthetic Biology and Bioengineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288209/ https://www.ncbi.nlm.nih.gov/pubmed/25326321 http://dx.doi.org/10.1093/nar/gku971

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