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Optimizing the data combination rule for seamless phase II/III clinical trials
We consider seamless phase II/III clinical trials that compare K treatments with a common control in phase II then test the most promising treatment against control in phase III. The final hypothesis test for the selected treatment can use data from both phases, subject to controlling the familywise...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BlackWell Publishing Ltd
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288236/ https://www.ncbi.nlm.nih.gov/pubmed/25315892 http://dx.doi.org/10.1002/sim.6316 |