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Endometrial stem cell transplantation in MPTP- exposed primates: an alternative cell source for treatment of Parkinson's disease

Parkinson's disease (PD) is a neurodegenerative disease caused by the loss of dopaminergic neurons in the substantia nigra. Cell-replacement therapies have emerged as a promising strategy to slow down or replace neuronal loss. Compared to other stem cell types, endometrium-derived stem cells (E...

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Detalles Bibliográficos
Autores principales: Wolff, Erin F, Mutlu, Levent, Massasa, Efi E, Elsworth, John D, Eugene Redmond, D, Taylor, Hugh S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288367/
https://www.ncbi.nlm.nih.gov/pubmed/25283241
http://dx.doi.org/10.1111/jcmm.12433
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author Wolff, Erin F
Mutlu, Levent
Massasa, Efi E
Elsworth, John D
Eugene Redmond, D
Taylor, Hugh S
author_facet Wolff, Erin F
Mutlu, Levent
Massasa, Efi E
Elsworth, John D
Eugene Redmond, D
Taylor, Hugh S
author_sort Wolff, Erin F
collection PubMed
description Parkinson's disease (PD) is a neurodegenerative disease caused by the loss of dopaminergic neurons in the substantia nigra. Cell-replacement therapies have emerged as a promising strategy to slow down or replace neuronal loss. Compared to other stem cell types, endometrium-derived stem cells (EDSCs) are an attractive source of stem cells for cellular therapies because of their ease of collection and vast differentiation potential. Here we demonstrate that endometrium-derived stem cells may be transplanted into an MPTP exposed monkey model of PD. After injection into the striatum, endometrium-derived stem cells engrafted, exhibited neuron-like morphology, expressed tyrosine hydroxylase (TH) and increased the numbers of TH positive cells on the transplanted side and dopamine metabolite concentrations in vivo. Our results suggest that endometrium-derived stem cells may provide a therapeutic benefit in the primate model of PD and may be used in stem cell based therapies.
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spelling pubmed-42883672015-01-21 Endometrial stem cell transplantation in MPTP- exposed primates: an alternative cell source for treatment of Parkinson's disease Wolff, Erin F Mutlu, Levent Massasa, Efi E Elsworth, John D Eugene Redmond, D Taylor, Hugh S J Cell Mol Med Original Articles Parkinson's disease (PD) is a neurodegenerative disease caused by the loss of dopaminergic neurons in the substantia nigra. Cell-replacement therapies have emerged as a promising strategy to slow down or replace neuronal loss. Compared to other stem cell types, endometrium-derived stem cells (EDSCs) are an attractive source of stem cells for cellular therapies because of their ease of collection and vast differentiation potential. Here we demonstrate that endometrium-derived stem cells may be transplanted into an MPTP exposed monkey model of PD. After injection into the striatum, endometrium-derived stem cells engrafted, exhibited neuron-like morphology, expressed tyrosine hydroxylase (TH) and increased the numbers of TH positive cells on the transplanted side and dopamine metabolite concentrations in vivo. Our results suggest that endometrium-derived stem cells may provide a therapeutic benefit in the primate model of PD and may be used in stem cell based therapies. Blackwell Publishing Ltd 2015-01 2014-10-06 /pmc/articles/PMC4288367/ /pubmed/25283241 http://dx.doi.org/10.1111/jcmm.12433 Text en © 2014 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Wolff, Erin F
Mutlu, Levent
Massasa, Efi E
Elsworth, John D
Eugene Redmond, D
Taylor, Hugh S
Endometrial stem cell transplantation in MPTP- exposed primates: an alternative cell source for treatment of Parkinson's disease
title Endometrial stem cell transplantation in MPTP- exposed primates: an alternative cell source for treatment of Parkinson's disease
title_full Endometrial stem cell transplantation in MPTP- exposed primates: an alternative cell source for treatment of Parkinson's disease
title_fullStr Endometrial stem cell transplantation in MPTP- exposed primates: an alternative cell source for treatment of Parkinson's disease
title_full_unstemmed Endometrial stem cell transplantation in MPTP- exposed primates: an alternative cell source for treatment of Parkinson's disease
title_short Endometrial stem cell transplantation in MPTP- exposed primates: an alternative cell source for treatment of Parkinson's disease
title_sort endometrial stem cell transplantation in mptp- exposed primates: an alternative cell source for treatment of parkinson's disease
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288367/
https://www.ncbi.nlm.nih.gov/pubmed/25283241
http://dx.doi.org/10.1111/jcmm.12433
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