Cargando…
IL-12 stimuli during ex vivo expansion not only prevents the upregulation of PD1 on tumor infiltrating adoptively transferred T cells but also on endogenous TILs which results in effective tumor regression
Autores principales: | Diaz-Montero, C Marcela, Yang, Yu, Rayman, Patricia A, Montero, Alberto, Tannenbaum, Charlie, Finke, James |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288377/ http://dx.doi.org/10.1186/2051-1426-2-S3-P10 |
Ejemplares similares
-
Ex vivo conditioning with IL-12 decreases T cell sensitivity to intratumoral INF-γ-induced apoptosis following adoptive transfer
por: Diaz-Montero, C Marcela, et al.
Publicado: (2015) -
Modulation of immune cell infiltrate with sunitinib to improve anti-PD1 therapy in preclinical tumor model
por: Rayman, Patricia, et al.
Publicado: (2015) -
Accumulation of MDSC subsets in renal cell carcinoma correlates with grade and progression free survival, and is associated with intratumoral expression of IL-1β, IL-8 and CXCL5
por: Najjar, Yana G, et al.
Publicado: (2014) -
Adoptive TIL in HPV-negative oral scca
por: Leidner, Rom, et al.
Publicado: (2015) -
Expansion of tumor-infiltrating lymphocytes (TIL) from human pancreatic tumors
por: Hall, MacLean, et al.
Publicado: (2016)