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Dexamethasone Reduces Nausea and Vomiting but not Pain after Thyroid Surgery: A Meta-Analysis of Randomized Controlled Trials

BACKGROUND: Postoperative nausea and vomiting (PONV) is a common complication after thyroidectomy. The aim of this article was to evaluate the efficacy of dexamethasone for prevention of PONV and pain in patients undergoing thyroidectomy. MATERIAL/METHODS: We performed this meta-analysis based on th...

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Autores principales: Li, Bo, Wang, Huixia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288396/
https://www.ncbi.nlm.nih.gov/pubmed/25549754
http://dx.doi.org/10.12659/MSM.891390
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author Li, Bo
Wang, Huixia
author_facet Li, Bo
Wang, Huixia
author_sort Li, Bo
collection PubMed
description BACKGROUND: Postoperative nausea and vomiting (PONV) is a common complication after thyroidectomy. The aim of this article was to evaluate the efficacy of dexamethasone for prevention of PONV and pain in patients undergoing thyroidectomy. MATERIAL/METHODS: We performed this meta-analysis based on the QUORUM (Quality of Reporting of Meta-analyses) guidelines. Our study included randomized controlled trials (RCTs) that compared preoperative single-dose administration of dexamethasone with no dexamethasone in patients undergoing thyroidectomy. The primary outcome was occurrence and severity of PONV, and the secondary outcomes included pain, use of analgesics, and steroid-related complications. RESULTS: Seven RCTs were included, with a total of 611 patients. A statistically and clinically significant difference in the incidence and severity of PONV was found in favor of dexamethasone (SMD, 0.23; 95% CI, 0.13–0.41; P<0.00001; SMD, 0.53; 95% CI, −1.03 to −0.03; P=0.04). However, there was no significant difference in reduction of pain severity and analgesic consumption in using dexamethasone (SMD, −0.83; 95% CI, −1.85 to 0.18; P=0.14; SMD, −0.19; 95% CI, −0.43 to 0.04; P=0.10). No steroid-related complications were noted. CONCLUSIONS: A single preoperative administration of dexamethasone reduced the incidence and severity of PONV but not pain severity and analgesic consumption in patients undergoing thyroidectomy. Further studies with a larger sample size are needed to further explore the efficacy of dexamethasone on postoperative pain severity and analgesic consumption.
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spelling pubmed-42883962015-01-12 Dexamethasone Reduces Nausea and Vomiting but not Pain after Thyroid Surgery: A Meta-Analysis of Randomized Controlled Trials Li, Bo Wang, Huixia Med Sci Monit Meta-Analysis BACKGROUND: Postoperative nausea and vomiting (PONV) is a common complication after thyroidectomy. The aim of this article was to evaluate the efficacy of dexamethasone for prevention of PONV and pain in patients undergoing thyroidectomy. MATERIAL/METHODS: We performed this meta-analysis based on the QUORUM (Quality of Reporting of Meta-analyses) guidelines. Our study included randomized controlled trials (RCTs) that compared preoperative single-dose administration of dexamethasone with no dexamethasone in patients undergoing thyroidectomy. The primary outcome was occurrence and severity of PONV, and the secondary outcomes included pain, use of analgesics, and steroid-related complications. RESULTS: Seven RCTs were included, with a total of 611 patients. A statistically and clinically significant difference in the incidence and severity of PONV was found in favor of dexamethasone (SMD, 0.23; 95% CI, 0.13–0.41; P<0.00001; SMD, 0.53; 95% CI, −1.03 to −0.03; P=0.04). However, there was no significant difference in reduction of pain severity and analgesic consumption in using dexamethasone (SMD, −0.83; 95% CI, −1.85 to 0.18; P=0.14; SMD, −0.19; 95% CI, −0.43 to 0.04; P=0.10). No steroid-related complications were noted. CONCLUSIONS: A single preoperative administration of dexamethasone reduced the incidence and severity of PONV but not pain severity and analgesic consumption in patients undergoing thyroidectomy. Further studies with a larger sample size are needed to further explore the efficacy of dexamethasone on postoperative pain severity and analgesic consumption. International Scientific Literature, Inc. 2014-12-31 /pmc/articles/PMC4288396/ /pubmed/25549754 http://dx.doi.org/10.12659/MSM.891390 Text en © Med Sci Monit, 2014 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License
spellingShingle Meta-Analysis
Li, Bo
Wang, Huixia
Dexamethasone Reduces Nausea and Vomiting but not Pain after Thyroid Surgery: A Meta-Analysis of Randomized Controlled Trials
title Dexamethasone Reduces Nausea and Vomiting but not Pain after Thyroid Surgery: A Meta-Analysis of Randomized Controlled Trials
title_full Dexamethasone Reduces Nausea and Vomiting but not Pain after Thyroid Surgery: A Meta-Analysis of Randomized Controlled Trials
title_fullStr Dexamethasone Reduces Nausea and Vomiting but not Pain after Thyroid Surgery: A Meta-Analysis of Randomized Controlled Trials
title_full_unstemmed Dexamethasone Reduces Nausea and Vomiting but not Pain after Thyroid Surgery: A Meta-Analysis of Randomized Controlled Trials
title_short Dexamethasone Reduces Nausea and Vomiting but not Pain after Thyroid Surgery: A Meta-Analysis of Randomized Controlled Trials
title_sort dexamethasone reduces nausea and vomiting but not pain after thyroid surgery: a meta-analysis of randomized controlled trials
topic Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288396/
https://www.ncbi.nlm.nih.gov/pubmed/25549754
http://dx.doi.org/10.12659/MSM.891390
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