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Does the linear Sry transcript function as a ceRNA for miR-138? The sense of antisense
Recently, the sex determining region Y ( Sry) and the cerebellar degeneration-related protein 1 ( CDR1as) RNA transcripts have been described to function as a new class of post-transcriptional regulatory RNAs that behave as circular endogenous RNA sponges for the micro RNAs (miRNAs) miR-138 and miR-...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000Research
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288412/ https://www.ncbi.nlm.nih.gov/pubmed/25580223 http://dx.doi.org/10.12688/f1000research.3872.2 |
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author | Granados-Riveron, Javier Tadeo Aquino-Jarquin, Guillermo |
author_facet | Granados-Riveron, Javier Tadeo Aquino-Jarquin, Guillermo |
author_sort | Granados-Riveron, Javier Tadeo |
collection | PubMed |
description | Recently, the sex determining region Y ( Sry) and the cerebellar degeneration-related protein 1 ( CDR1as) RNA transcripts have been described to function as a new class of post-transcriptional regulatory RNAs that behave as circular endogenous RNA sponges for the micro RNAs (miRNAs) miR-138 and miR-7, respectively. A special feature of the Sry gene is its ability to generate linear and circular transcripts, both transcribed in the sense orientation. Here we remark that both sense (e.g. Sry RNA) and antisense (e.g. CDR1as) transcripts could circularize and behave as miRNAs sponges, and importantly, that also protein-coding segments of mRNAs could also assume this role. Thus, it is reasonable to think that the linear Sry sense transcript could additionally act as a miRNA sponge, or as an endogenous competing RNA for miR-138. |
format | Online Article Text |
id | pubmed-4288412 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | F1000Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-42884122015-01-09 Does the linear Sry transcript function as a ceRNA for miR-138? The sense of antisense Granados-Riveron, Javier Tadeo Aquino-Jarquin, Guillermo F1000Res Correspondence Recently, the sex determining region Y ( Sry) and the cerebellar degeneration-related protein 1 ( CDR1as) RNA transcripts have been described to function as a new class of post-transcriptional regulatory RNAs that behave as circular endogenous RNA sponges for the micro RNAs (miRNAs) miR-138 and miR-7, respectively. A special feature of the Sry gene is its ability to generate linear and circular transcripts, both transcribed in the sense orientation. Here we remark that both sense (e.g. Sry RNA) and antisense (e.g. CDR1as) transcripts could circularize and behave as miRNAs sponges, and importantly, that also protein-coding segments of mRNAs could also assume this role. Thus, it is reasonable to think that the linear Sry sense transcript could additionally act as a miRNA sponge, or as an endogenous competing RNA for miR-138. F1000Research 2014-11-13 /pmc/articles/PMC4288412/ /pubmed/25580223 http://dx.doi.org/10.12688/f1000research.3872.2 Text en Copyright: © 2014 Granados-Riveron JT and Aquino-Jarquin G http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/publicdomain/zero/1.0/ Data associated with the article are available under the terms of the Creative Commons Zero "No rights reserved" data waiver (CC0 1.0 Public domain dedication). |
spellingShingle | Correspondence Granados-Riveron, Javier Tadeo Aquino-Jarquin, Guillermo Does the linear Sry transcript function as a ceRNA for miR-138? The sense of antisense |
title | Does the linear
Sry transcript function as a ceRNA for miR-138? The sense of antisense |
title_full | Does the linear
Sry transcript function as a ceRNA for miR-138? The sense of antisense |
title_fullStr | Does the linear
Sry transcript function as a ceRNA for miR-138? The sense of antisense |
title_full_unstemmed | Does the linear
Sry transcript function as a ceRNA for miR-138? The sense of antisense |
title_short | Does the linear
Sry transcript function as a ceRNA for miR-138? The sense of antisense |
title_sort | does the linear
sry transcript function as a cerna for mir-138? the sense of antisense |
topic | Correspondence |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288412/ https://www.ncbi.nlm.nih.gov/pubmed/25580223 http://dx.doi.org/10.12688/f1000research.3872.2 |
work_keys_str_mv | AT granadosriveronjaviertadeo doesthelinearsrytranscriptfunctionasacernaformir138thesenseofantisense AT aquinojarquinguillermo doesthelinearsrytranscriptfunctionasacernaformir138thesenseofantisense |