Cargando…

Comparison of immune modulation by TLR8 agonist vtx-2337 (motolimod) in cancer patients and healthy volunteers

Detalles Bibliográficos
Autores principales:	Dietsch, Greg, Whiting, Sam, Northfelt, Donald, Ramanathan, Ramesh, Cohen, Peter, Manjarrez, Kristi, Newkirk, Mona, Bryan, James Kyle, Hershberg, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Poster Presentation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288547/ http://dx.doi.org/10.1186/2051-1426-2-S3-P165

Ejemplares similares

Active8: a randomized, double-blind, placebo-controlled study of chemotherapy plus cetuximab in combination with TLR8 agonist VTX-2337 in patients with recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN)
por: Ferris, Robert L, et al.
Publicado: (2014)

TLR8 agonist VTX-2337 enhances NKG2D-mediated cytotoxicity of NK cells
por: Lu, Hailing, et al.
Publicado: (2013)

Coordinated Activation of Toll-Like Receptor8 (TLR8) and NLRP3 by the TLR8 Agonist, VTX-2337, Ignites Tumoricidal Natural Killer Cell Activity
por: Dietsch, Gregory N., et al.
Publicado: (2016)

Motolimod, a selective TLR8 agonist induces apoptosis in monocytic myeloid-derived suppressor cells (M-MDSC)
por: Rutnam, Zina J, et al.
Publicado: (2015)

The Ultra-Potent and Selective TLR8 Agonist VTX-294 Activates Human Newborn and Adult Leukocytes
por: Dowling, David J., et al.
Publicado: (2013)

VTX‐1463, a novel TLR‐8 agonist, attenuates nasal congestion after ragweed challenge in sensitized beagle dogs
por: Royer, Christopher M., et al.
Publicado: (2015)

The anti-tumor effects of cetuximab in combination with VTX-2337 are T cell dependent
por: Cheng, Yinwen, et al.
Publicado: (2021)

Motolimod effectively drives immune activation in advanced cancer patients
por: Dietsch, Gregory N.
Publicado: (2016)

A Phase Ib study of neoadjuvant immune biomarker modulation with cetuximab and motolimod in head and neck cancer (HNC)
por: Ferris, Robert L, et al.
Publicado: (2015)

A novel TLR-8 agonist attenuates nasal symptoms/congestion in both dog and human allergen challenge studies
por: Barrett, Edward G, et al.
Publicado: (2013)

A phase 2, randomized, double-blind, placebo- controlled study of chemo-immunotherapy combination using motolimod with pegylated liposomal doxorubicin in recurrent or persistent ovarian cancer: a Gynecologic Oncology Group partners study
por: Monk, B. J., et al.
Publicado: (2017)

Whole genome sequence comparison of vtx2-converting phages from Enteroaggregative Haemorrhagic Escherichia coli strains
por: Grande, Laura, et al.
Publicado: (2014)

PReS-FINAL-2337: The eurofever registry: 3 years of enrollment
por: Federici, S, et al.
Publicado: (2013)

Safety, tolerability, pharmacokinetics, and pharmacodynamics of a TLR7 agonist prodrug RO6870868 in healthy volunteers
por: Grippo, Joseph F., et al.
Publicado: (2021)

VTX‐1 Liquid Biopsy System for Fully‐Automated and Label‐Free Isolation of Circulating Tumor Cells with Automated Enumeration by BioView Platform
por: Sollier‐Christen, Elodie, et al.
Publicado: (2018)

2337: Doxorubicin exposure in vitro stimulates ROS production and directly suppresses cardiac fibroblast proliferation
por: Mancilla, Trevi A., et al.
Publicado: (2018)

Deoxyguanosine is a TLR7 agonist
por: Davenne, Tamara, et al.
Publicado: (2019)

NOD2 Agonist Promotes the Production of Inflammatory Cytokines in VSMC in Synergy with TLR2 and TLR4 Agonists
por: Sun, Jinghua, et al.
Publicado: (2012)

2337. Clinical Characteristics of Children Infected With Macrolide-Resistant Mycoplasma Pneumonia in Central Ohio—Preliminary Data
por: Piazzon, Mariana Lanata, et al.
Publicado: (2018)

2337. Health Outcomes in Congenital Cytomegalovirus, a Systematized and Unbiased Approach in the Electronic Medical Record Era
por: Rochat, Ryan H, et al.
Publicado: (2019)

Comparison of human B cell activation by TLR7 and TLR9 agonists
por: Hanten, John A, et al.
Publicado: (2008)

Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists
por: Cheng, Kui, et al.
Publicado: (2015)

Trial Watch: experimental TLR7/TLR8 agonists for oncological indications
por: Frega, Giorgio, et al.
Publicado: (2020)

Loss of vtx Genes after the First Subcultivation Step of Verocytotoxigenic Escherichia coli O157 and Non-O157 during Isolation from Naturally Contaminated Fecal Samples
por: Joris, Maria-Adelheid, et al.
Publicado: (2011)

PB2337: SHORT-TERM EFFICACY AND SAFETY OF ZANUBRUTINIB COMBINED WITH POMALIDOMIDE IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM LYMPHOMA
por: Zhang, Zhipeng, et al.
Publicado: (2023)

Liposomal TLR9 Agonist Combined with TLR2 Agonist-Fused Antigen Can Modulate Tumor Microenvironment through Dendritic Cells
por: Shen, Kuan-Yin, et al.
Publicado: (2020)

Statement of Retraction. Physical Exercise Reduces Circulating Lipopolysaccharide and TLR4 Activation and Improves Insulin Signaling in Tissues of DIO Rats. Diabetes 2011;60:784–796. DOI: 10.2337/db09-1907
por: Oliveira, Alexandre G., et al.
Publicado: (2016)

miR-2337 induces TGF-β1 production in granulosa cells by acting as an endogenous small activating RNA
por: Wang, Lingfang, et al.
Publicado: (2021)

Microbial TLR Agonists and Humoral Immunopathogenesis in HIV Disease
por: Yu, Xiaocong, et al.
Publicado: (2013)

Trial watch: TLR3 agonists in cancer therapy
por: Le Naour, Julie, et al.
Publicado: (2020)

OMV Vaccines and the Role of TLR Agonists in Immune Response
por: Mancini, Francesca, et al.
Publicado: (2020)

Formulated Phospholipids as Non-Canonical TLR4 Agonists
por: Liang, Hong, et al.
Publicado: (2022)

TLR Agonist Therapy of Metastatic Breast Cancer in Mice
por: Klinman, Dennis M., et al.
Publicado: (2023)

TLR3 and TLR9 Agonists Improve Postexposure Vaccination Efficacy of Live Smallpox Vaccines
por: Israely, Tomer, et al.
Publicado: (2014)

Overexpression of TLR2 and TLR9 on monocyte subsets of active rheumatoid arthritis patients contributes to enhance responsiveness to TLR agonists
por: Lacerte, Patricia, et al.
Publicado: (2016)

The combination of TLR2 and TLR4 agonists promotes the immunogenicity of dendritic cell/cancer cell fusions
por: Koido, Shigeo, et al.
Publicado: (2013)

Development of N-Acetylated Dipalmitoyl-S-Glyceryl Cysteine Analogs as Efficient TLR2/TLR6 Agonists
por: Zhou, Yang, et al.
Publicado: (2019)

Molecular dynamics simulations reveal the selectivity mechanism of structurally similar agonists to TLR7 and TLR8
por: Wang, Xiaoyu, et al.
Publicado: (2022)

Cytokine Effect of TLR3, TLR4, and TLR7 Agonists Alone or Associated with Leishmania infantum Antigen on Blood from Dogs
por: Martínez-Orellana, Pamela, et al.
Publicado: (2018)

Differential Response of Gestational Tissues to TLR3 Viral Priming Prior to Exposure to Bacterial TLR2 and TLR2/6 Agonists
por: Rasheed, Zahirrah B. M., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_th4pntu3hkkuaic8beqm4keqpt