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Modulation of endothelin receptors in the failing right ventricle of the heart and vasculature of the lung in human pulmonary arterial hypertension

AIMS: In pulmonary arterial hypertension (PAH), increases in endothelin-1 (ET-1) contribute to elevated pulmonary vascular resistance which ultimately causes death by right ventricular (RV) heart failure. ET antagonists are effective in treating PAH but lack efficacy in treating left ventricular (LV...

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Detalles Bibliográficos
Autores principales:	Kuc, Rhoda E., Carlebur, Myrna, Maguire, Janet J., Yang, Peiran, Long, Lu, Toshner, Mark, Morrell, Nicholas W., Davenport, Anthony P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288792/ https://www.ncbi.nlm.nih.gov/pubmed/24582810 http://dx.doi.org/10.1016/j.lfs.2014.02.020

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