Cargando…

Epidemiology and Individual, Household and Geographical Risk Factors of Podoconiosis in Ethiopia: Results from the First Nationwide Mapping

Although podoconiosis is one of the major causes of tropical lymphoedema and is endemic in Ethiopia its epidemiology and risk factors are poorly understood. Individual-level data for 129,959 individuals from 1,315 communities in 659 woreda (districts) were collected for a nationwide integrated surve...

Descripción completa

Detalles Bibliográficos
Autores principales: Deribe, Kebede, Brooker, Simon J., Pullan, Rachel L., Sime, Heven, Gebretsadik, Abeba, Assefa, Ashenafi, Kebede, Amha, Hailu, Asrat, Rebollo, Maria P., Shafi, Oumer, Bockarie, Moses J., Aseffa, Abraham, Reithinger, Richard, Cano, Jorge, Enquselassie, Fikre, Newport, Melanie J., Davey, Gail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288951/
https://www.ncbi.nlm.nih.gov/pubmed/25404069
http://dx.doi.org/10.4269/ajtmh.14-0446
_version_ 1782352033111605248
author Deribe, Kebede
Brooker, Simon J.
Pullan, Rachel L.
Sime, Heven
Gebretsadik, Abeba
Assefa, Ashenafi
Kebede, Amha
Hailu, Asrat
Rebollo, Maria P.
Shafi, Oumer
Bockarie, Moses J.
Aseffa, Abraham
Reithinger, Richard
Cano, Jorge
Enquselassie, Fikre
Newport, Melanie J.
Davey, Gail
author_facet Deribe, Kebede
Brooker, Simon J.
Pullan, Rachel L.
Sime, Heven
Gebretsadik, Abeba
Assefa, Ashenafi
Kebede, Amha
Hailu, Asrat
Rebollo, Maria P.
Shafi, Oumer
Bockarie, Moses J.
Aseffa, Abraham
Reithinger, Richard
Cano, Jorge
Enquselassie, Fikre
Newport, Melanie J.
Davey, Gail
author_sort Deribe, Kebede
collection PubMed
description Although podoconiosis is one of the major causes of tropical lymphoedema and is endemic in Ethiopia its epidemiology and risk factors are poorly understood. Individual-level data for 129,959 individuals from 1,315 communities in 659 woreda (districts) were collected for a nationwide integrated survey of lymphatic filariasis and podoconiosis. Blood samples were tested for circulating Wuchereria bancrofti antigen using immunochromatographic card tests. A clinical algorithm was used to reach a diagnosis of podoconiosis by excluding other potential causes of lymphoedema of the lower limb. Bayesian multilevel models were used to identify individual and environmental risk factors. Overall, 8,110 of 129,959 (6.2%, 95% confidence interval [CI] 6.1–6.4%) surveyed individuals were identified with lymphoedema of the lower limb, of whom 5,253 (4.0%, 95% CI 3.9–4.1%) were confirmed to be podoconiosis cases. In multivariable analysis, being female, older, unmarried, washing the feet less frequently than daily, and being semiskilled or unemployed were significantly associated with increased risk of podoconiosis. Attending formal education and living in a house with a covered floor were associated with decreased risk of podoconiosis. Podoconiosis exhibits marked geographical variation across Ethiopia, with variation in risk associated with variation in rainfall, enhanced vegetation index, and altitude.
format Online
Article
Text
id pubmed-4288951
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher The American Society of Tropical Medicine and Hygiene
record_format MEDLINE/PubMed
spelling pubmed-42889512015-01-10 Epidemiology and Individual, Household and Geographical Risk Factors of Podoconiosis in Ethiopia: Results from the First Nationwide Mapping Deribe, Kebede Brooker, Simon J. Pullan, Rachel L. Sime, Heven Gebretsadik, Abeba Assefa, Ashenafi Kebede, Amha Hailu, Asrat Rebollo, Maria P. Shafi, Oumer Bockarie, Moses J. Aseffa, Abraham Reithinger, Richard Cano, Jorge Enquselassie, Fikre Newport, Melanie J. Davey, Gail Am J Trop Med Hyg Articles Although podoconiosis is one of the major causes of tropical lymphoedema and is endemic in Ethiopia its epidemiology and risk factors are poorly understood. Individual-level data for 129,959 individuals from 1,315 communities in 659 woreda (districts) were collected for a nationwide integrated survey of lymphatic filariasis and podoconiosis. Blood samples were tested for circulating Wuchereria bancrofti antigen using immunochromatographic card tests. A clinical algorithm was used to reach a diagnosis of podoconiosis by excluding other potential causes of lymphoedema of the lower limb. Bayesian multilevel models were used to identify individual and environmental risk factors. Overall, 8,110 of 129,959 (6.2%, 95% confidence interval [CI] 6.1–6.4%) surveyed individuals were identified with lymphoedema of the lower limb, of whom 5,253 (4.0%, 95% CI 3.9–4.1%) were confirmed to be podoconiosis cases. In multivariable analysis, being female, older, unmarried, washing the feet less frequently than daily, and being semiskilled or unemployed were significantly associated with increased risk of podoconiosis. Attending formal education and living in a house with a covered floor were associated with decreased risk of podoconiosis. Podoconiosis exhibits marked geographical variation across Ethiopia, with variation in risk associated with variation in rainfall, enhanced vegetation index, and altitude. The American Society of Tropical Medicine and Hygiene 2015-01-07 /pmc/articles/PMC4288951/ /pubmed/25404069 http://dx.doi.org/10.4269/ajtmh.14-0446 Text en ©The American Society of Tropical Medicine and Hygiene This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Articles
Deribe, Kebede
Brooker, Simon J.
Pullan, Rachel L.
Sime, Heven
Gebretsadik, Abeba
Assefa, Ashenafi
Kebede, Amha
Hailu, Asrat
Rebollo, Maria P.
Shafi, Oumer
Bockarie, Moses J.
Aseffa, Abraham
Reithinger, Richard
Cano, Jorge
Enquselassie, Fikre
Newport, Melanie J.
Davey, Gail
Epidemiology and Individual, Household and Geographical Risk Factors of Podoconiosis in Ethiopia: Results from the First Nationwide Mapping
title Epidemiology and Individual, Household and Geographical Risk Factors of Podoconiosis in Ethiopia: Results from the First Nationwide Mapping
title_full Epidemiology and Individual, Household and Geographical Risk Factors of Podoconiosis in Ethiopia: Results from the First Nationwide Mapping
title_fullStr Epidemiology and Individual, Household and Geographical Risk Factors of Podoconiosis in Ethiopia: Results from the First Nationwide Mapping
title_full_unstemmed Epidemiology and Individual, Household and Geographical Risk Factors of Podoconiosis in Ethiopia: Results from the First Nationwide Mapping
title_short Epidemiology and Individual, Household and Geographical Risk Factors of Podoconiosis in Ethiopia: Results from the First Nationwide Mapping
title_sort epidemiology and individual, household and geographical risk factors of podoconiosis in ethiopia: results from the first nationwide mapping
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288951/
https://www.ncbi.nlm.nih.gov/pubmed/25404069
http://dx.doi.org/10.4269/ajtmh.14-0446
work_keys_str_mv AT deribekebede epidemiologyandindividualhouseholdandgeographicalriskfactorsofpodoconiosisinethiopiaresultsfromthefirstnationwidemapping
AT brookersimonj epidemiologyandindividualhouseholdandgeographicalriskfactorsofpodoconiosisinethiopiaresultsfromthefirstnationwidemapping
AT pullanrachell epidemiologyandindividualhouseholdandgeographicalriskfactorsofpodoconiosisinethiopiaresultsfromthefirstnationwidemapping
AT simeheven epidemiologyandindividualhouseholdandgeographicalriskfactorsofpodoconiosisinethiopiaresultsfromthefirstnationwidemapping
AT gebretsadikabeba epidemiologyandindividualhouseholdandgeographicalriskfactorsofpodoconiosisinethiopiaresultsfromthefirstnationwidemapping
AT assefaashenafi epidemiologyandindividualhouseholdandgeographicalriskfactorsofpodoconiosisinethiopiaresultsfromthefirstnationwidemapping
AT kebedeamha epidemiologyandindividualhouseholdandgeographicalriskfactorsofpodoconiosisinethiopiaresultsfromthefirstnationwidemapping
AT hailuasrat epidemiologyandindividualhouseholdandgeographicalriskfactorsofpodoconiosisinethiopiaresultsfromthefirstnationwidemapping
AT rebollomariap epidemiologyandindividualhouseholdandgeographicalriskfactorsofpodoconiosisinethiopiaresultsfromthefirstnationwidemapping
AT shafioumer epidemiologyandindividualhouseholdandgeographicalriskfactorsofpodoconiosisinethiopiaresultsfromthefirstnationwidemapping
AT bockariemosesj epidemiologyandindividualhouseholdandgeographicalriskfactorsofpodoconiosisinethiopiaresultsfromthefirstnationwidemapping
AT aseffaabraham epidemiologyandindividualhouseholdandgeographicalriskfactorsofpodoconiosisinethiopiaresultsfromthefirstnationwidemapping
AT reithingerrichard epidemiologyandindividualhouseholdandgeographicalriskfactorsofpodoconiosisinethiopiaresultsfromthefirstnationwidemapping
AT canojorge epidemiologyandindividualhouseholdandgeographicalriskfactorsofpodoconiosisinethiopiaresultsfromthefirstnationwidemapping
AT enquselassiefikre epidemiologyandindividualhouseholdandgeographicalriskfactorsofpodoconiosisinethiopiaresultsfromthefirstnationwidemapping
AT newportmelaniej epidemiologyandindividualhouseholdandgeographicalriskfactorsofpodoconiosisinethiopiaresultsfromthefirstnationwidemapping
AT daveygail epidemiologyandindividualhouseholdandgeographicalriskfactorsofpodoconiosisinethiopiaresultsfromthefirstnationwidemapping