Allosteric Activation of the RNF146 Ubiquitin Ligase by a Poly(ADP-ribosyl)ation Signal

Protein poly(ADP-ribosyl)ation (PARylation) plays a role in diverse cellular processes such as DNA repair, transcription, Wnt signaling, and cell death(1–6). Recent studies have shown that PARylation can serve as a signal for the polyubiquitination and degradation of several critical regulatory prot...

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Detalles Bibliográficos
Autores principales: DaRosa, Paul A., Wang, Zhizhi, Jiang, Xiaomo, Pruneda, Jonathan N., Cong, Feng, Klevit, Rachel E., Xu, Wenqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289021/
https://www.ncbi.nlm.nih.gov/pubmed/25327252
http://dx.doi.org/10.1038/nature13826

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