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Modular tumor endoprostheses in surgical palliation of long-bone metastases: a reduction in tumor burden and a durable reconstruction

BACKGROUND: Surgical treatment of bone metastases has become increasingly important as patients live longer with metastatic cancer and one of the main aims is a long-lasting reconstruction which survives the patient. Conventional osteosynthesis may not be able to achieve this objective in the contex...

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Autores principales: Henrichs, Marcel-Philipp, Krebs, Juliane, Gosheger, Georg, Streitbuerger, Arne, Nottrott, Markus, Sauer, Tim, Hoell, Steffen, Singh, Gurpal, Hardes, Jendrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289050/
https://www.ncbi.nlm.nih.gov/pubmed/25376274
http://dx.doi.org/10.1186/1477-7819-12-330
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author Henrichs, Marcel-Philipp
Krebs, Juliane
Gosheger, Georg
Streitbuerger, Arne
Nottrott, Markus
Sauer, Tim
Hoell, Steffen
Singh, Gurpal
Hardes, Jendrik
author_facet Henrichs, Marcel-Philipp
Krebs, Juliane
Gosheger, Georg
Streitbuerger, Arne
Nottrott, Markus
Sauer, Tim
Hoell, Steffen
Singh, Gurpal
Hardes, Jendrik
author_sort Henrichs, Marcel-Philipp
collection PubMed
description BACKGROUND: Surgical treatment of bone metastases has become increasingly important as patients live longer with metastatic cancer and one of the main aims is a long-lasting reconstruction which survives the patient. Conventional osteosynthesis may not be able to achieve this objective in the context of modern day cancer care. METHODS: This study evaluates the oncological outcomes, treatment-related complications, and function after resection of metastases and reconstruction with modular tumor endoprostheses in 80 patients. All patients who underwent surgical treatment with modular tumor prostheses for bone metastases from 1993 to 2008 were traced by our tumor database and clinical information was recorded from patient case. RESULTS: Mean age was 63 years. The most common primary tumors were renal cell (47%), breast (21%), and lung (8%). The proximal femur was affected in 45%, proximal humerus in 26%, and the distal femur in 17% of cases. In 22 cases, the tumor prosthesis was implanted during a revision operation. Mean overall survival after surgery was 2.9 years. Overall survival rate was 70% at one year and 20% at five years. Implant survival was 83% after one year and 74% at five years. Overall rate of operative revision was 18%. CONCLUSIONS: Our data collectively suggest that despite higher costs, implantation of modular tumor endoprostheses may be a suitable treatment for bone metastases with a low complication rate and rapid improvement in function in appropriately selected patients.
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spelling pubmed-42890502015-01-11 Modular tumor endoprostheses in surgical palliation of long-bone metastases: a reduction in tumor burden and a durable reconstruction Henrichs, Marcel-Philipp Krebs, Juliane Gosheger, Georg Streitbuerger, Arne Nottrott, Markus Sauer, Tim Hoell, Steffen Singh, Gurpal Hardes, Jendrik World J Surg Oncol Research BACKGROUND: Surgical treatment of bone metastases has become increasingly important as patients live longer with metastatic cancer and one of the main aims is a long-lasting reconstruction which survives the patient. Conventional osteosynthesis may not be able to achieve this objective in the context of modern day cancer care. METHODS: This study evaluates the oncological outcomes, treatment-related complications, and function after resection of metastases and reconstruction with modular tumor endoprostheses in 80 patients. All patients who underwent surgical treatment with modular tumor prostheses for bone metastases from 1993 to 2008 were traced by our tumor database and clinical information was recorded from patient case. RESULTS: Mean age was 63 years. The most common primary tumors were renal cell (47%), breast (21%), and lung (8%). The proximal femur was affected in 45%, proximal humerus in 26%, and the distal femur in 17% of cases. In 22 cases, the tumor prosthesis was implanted during a revision operation. Mean overall survival after surgery was 2.9 years. Overall survival rate was 70% at one year and 20% at five years. Implant survival was 83% after one year and 74% at five years. Overall rate of operative revision was 18%. CONCLUSIONS: Our data collectively suggest that despite higher costs, implantation of modular tumor endoprostheses may be a suitable treatment for bone metastases with a low complication rate and rapid improvement in function in appropriately selected patients. BioMed Central 2014-11-07 /pmc/articles/PMC4289050/ /pubmed/25376274 http://dx.doi.org/10.1186/1477-7819-12-330 Text en © Henrichs et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Henrichs, Marcel-Philipp
Krebs, Juliane
Gosheger, Georg
Streitbuerger, Arne
Nottrott, Markus
Sauer, Tim
Hoell, Steffen
Singh, Gurpal
Hardes, Jendrik
Modular tumor endoprostheses in surgical palliation of long-bone metastases: a reduction in tumor burden and a durable reconstruction
title Modular tumor endoprostheses in surgical palliation of long-bone metastases: a reduction in tumor burden and a durable reconstruction
title_full Modular tumor endoprostheses in surgical palliation of long-bone metastases: a reduction in tumor burden and a durable reconstruction
title_fullStr Modular tumor endoprostheses in surgical palliation of long-bone metastases: a reduction in tumor burden and a durable reconstruction
title_full_unstemmed Modular tumor endoprostheses in surgical palliation of long-bone metastases: a reduction in tumor burden and a durable reconstruction
title_short Modular tumor endoprostheses in surgical palliation of long-bone metastases: a reduction in tumor burden and a durable reconstruction
title_sort modular tumor endoprostheses in surgical palliation of long-bone metastases: a reduction in tumor burden and a durable reconstruction
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289050/
https://www.ncbi.nlm.nih.gov/pubmed/25376274
http://dx.doi.org/10.1186/1477-7819-12-330
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