Mutations in G protein beta subunits promote transformation and kinase inhibitor resistance

Activating mutations of G protein alpha subunits (Gα) occur in 4–5% of all human cancers(1) but oncogenic alterations in beta subunits (Gβ) have not been defined. Here we demonstrate that recurrent mutations in the Gβ proteins GNB1 and GNB2 confer cytokine-independent growth and activate canonical G...

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Detalles Bibliográficos
Autores principales: Yoda, Akinori, Adelmant, Guillaume, Tamburini, Jerome, Chapuy, Bjoern, Shindoh, Nobuaki, Yoda, Yuka, Weigert, Oliver, Kopp, Nadja, Wu, Shuo-Chieh, Kim, Sunhee S., Liu, Huiyun, Tivey, Trevor, Christie, Amanda L., Elpek, Kutlu G., Card, Joseph, Gritsman, Kira, Gotlib, Jason, Deininger, Michael W., Makishima, Hideki, Turley, Shannon J., Javidi-Sharifi, Nathalie, Maciejewski, Jaroslaw P., Jaiswal, Siddhartha, Ebert, Benjamin L., Rodig, Scott J., Tyner, Jeffrey W., Marto, Jarrod A., Weinstock, David M., Lane, Andrew A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289115/
https://www.ncbi.nlm.nih.gov/pubmed/25485910
http://dx.doi.org/10.1038/nm.3751

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