Dynamics of double strand breaks and chromosomal translocations

Chromosomal translocations are a major cause of cancer. At the same time, the mechanisms that lead to specific chromosomal translocations that associate different gene regions remain largely unknown. Translocations are induced by double strand breaks (DSBs) in DNA. Here we review recent data on the...

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Autores principales: Iarovaia, Olga V, Rubtsov, Mikhail, Ioudinkova, Elena, Tsfasman, Tatiana, Razin, Sergey V, Vassetzky, Yegor S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289179/
https://www.ncbi.nlm.nih.gov/pubmed/25404525
http://dx.doi.org/10.1186/1476-4598-13-249
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author Iarovaia, Olga V
Rubtsov, Mikhail
Ioudinkova, Elena
Tsfasman, Tatiana
Razin, Sergey V
Vassetzky, Yegor S
author_facet Iarovaia, Olga V
Rubtsov, Mikhail
Ioudinkova, Elena
Tsfasman, Tatiana
Razin, Sergey V
Vassetzky, Yegor S
author_sort Iarovaia, Olga V
collection PubMed
description Chromosomal translocations are a major cause of cancer. At the same time, the mechanisms that lead to specific chromosomal translocations that associate different gene regions remain largely unknown. Translocations are induced by double strand breaks (DSBs) in DNA. Here we review recent data on the mechanisms of generation, mobility and repair of DSBs and stress the importance of the nuclear organization in this process.
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spelling pubmed-42891792015-01-11 Dynamics of double strand breaks and chromosomal translocations Iarovaia, Olga V Rubtsov, Mikhail Ioudinkova, Elena Tsfasman, Tatiana Razin, Sergey V Vassetzky, Yegor S Mol Cancer Review Chromosomal translocations are a major cause of cancer. At the same time, the mechanisms that lead to specific chromosomal translocations that associate different gene regions remain largely unknown. Translocations are induced by double strand breaks (DSBs) in DNA. Here we review recent data on the mechanisms of generation, mobility and repair of DSBs and stress the importance of the nuclear organization in this process. BioMed Central 2014-11-18 /pmc/articles/PMC4289179/ /pubmed/25404525 http://dx.doi.org/10.1186/1476-4598-13-249 Text en © Iarovaia et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Iarovaia, Olga V
Rubtsov, Mikhail
Ioudinkova, Elena
Tsfasman, Tatiana
Razin, Sergey V
Vassetzky, Yegor S
Dynamics of double strand breaks and chromosomal translocations
title Dynamics of double strand breaks and chromosomal translocations
title_full Dynamics of double strand breaks and chromosomal translocations
title_fullStr Dynamics of double strand breaks and chromosomal translocations
title_full_unstemmed Dynamics of double strand breaks and chromosomal translocations
title_short Dynamics of double strand breaks and chromosomal translocations
title_sort dynamics of double strand breaks and chromosomal translocations
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289179/
https://www.ncbi.nlm.nih.gov/pubmed/25404525
http://dx.doi.org/10.1186/1476-4598-13-249
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