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Is vulnerability to cardiometabolic disease in Indians mediated by abdominal adiposity or higher body adiposity
BACKGROUND: Indians may be particularly vulnerable to cardiometabolic disease, potentially due to higher body fat for a given BMI, or a tendency towards depositing abdominal adiposity. The aim of the study is to assess whether different measures of the distribution of adiposity (abdominal versus who...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289237/ https://www.ncbi.nlm.nih.gov/pubmed/25438835 http://dx.doi.org/10.1186/1471-2458-14-1239 |
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author | Kuper, Hannah Taylor, Amy Krishna, Kankipati Vijay Radha Ben-Shlomo, Yoav Gupta, Ruby Kulkarni, Bharati Prabhakaran, Dorairaj Davey Smith, George Wells, Jonathan Ebrahim, Shah Kinra, Sanjay |
author_facet | Kuper, Hannah Taylor, Amy Krishna, Kankipati Vijay Radha Ben-Shlomo, Yoav Gupta, Ruby Kulkarni, Bharati Prabhakaran, Dorairaj Davey Smith, George Wells, Jonathan Ebrahim, Shah Kinra, Sanjay |
author_sort | Kuper, Hannah |
collection | PubMed |
description | BACKGROUND: Indians may be particularly vulnerable to cardiometabolic disease, potentially due to higher body fat for a given BMI, or a tendency towards depositing abdominal adiposity. The aim of the study is to assess whether different measures of the distribution of adiposity (abdominal versus whole body) or amount of adiposity (DXA versus traditional anthropometric) are better at predicting prevalent cardiometabolic risk markers in an Indian population. METHODS: Participants were recruited from the Indian Migration Study (IMS) and the Andhra Pradesh Children and Parent Study (APCAPS). Participants attended a clinic in Hyderabad, India, January 2009-December 2010. Adiposity was measured by conventional anthropometry (including weight, height, waist) and DXA scanning (whole body and abdominal). Blood samples were taken and assessed for fasting plasma glucose, insulin, cholesterol, and triglycerides and blood pressure was measured. Lifestyle data were collected by questionnaire. RESULTS: We invited 4 617 participants to the clinic (1 995 IMS; 2 622 APCAPS) and examined 918 from IMS (46%) and 1 451 from APCAPS (55%). There were strong and consistent relationships between adiposity and cardiometabolic risk factors. Cardiometabolic risk factors did not appear to be more strongly associated with DXA measures as opposed to BMI, or skinfold measures of body fat. There was some evidence that WHR was more closely related to diabetes than total body adiposity, but this was not apparent for the other measures of abdominal adiposity (DXA measures, waist circumference) or other cardiometablic risk factors. CONCLUSIONS: No strong evidence supports that DXA measures or abdominal measures of adiposity are better at predicting the prevalence of cardiometabolic risk factors in comparison to BMI. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/1471-2458-14-1239) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4289237 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-42892372015-01-11 Is vulnerability to cardiometabolic disease in Indians mediated by abdominal adiposity or higher body adiposity Kuper, Hannah Taylor, Amy Krishna, Kankipati Vijay Radha Ben-Shlomo, Yoav Gupta, Ruby Kulkarni, Bharati Prabhakaran, Dorairaj Davey Smith, George Wells, Jonathan Ebrahim, Shah Kinra, Sanjay BMC Public Health Research Article BACKGROUND: Indians may be particularly vulnerable to cardiometabolic disease, potentially due to higher body fat for a given BMI, or a tendency towards depositing abdominal adiposity. The aim of the study is to assess whether different measures of the distribution of adiposity (abdominal versus whole body) or amount of adiposity (DXA versus traditional anthropometric) are better at predicting prevalent cardiometabolic risk markers in an Indian population. METHODS: Participants were recruited from the Indian Migration Study (IMS) and the Andhra Pradesh Children and Parent Study (APCAPS). Participants attended a clinic in Hyderabad, India, January 2009-December 2010. Adiposity was measured by conventional anthropometry (including weight, height, waist) and DXA scanning (whole body and abdominal). Blood samples were taken and assessed for fasting plasma glucose, insulin, cholesterol, and triglycerides and blood pressure was measured. Lifestyle data were collected by questionnaire. RESULTS: We invited 4 617 participants to the clinic (1 995 IMS; 2 622 APCAPS) and examined 918 from IMS (46%) and 1 451 from APCAPS (55%). There were strong and consistent relationships between adiposity and cardiometabolic risk factors. Cardiometabolic risk factors did not appear to be more strongly associated with DXA measures as opposed to BMI, or skinfold measures of body fat. There was some evidence that WHR was more closely related to diabetes than total body adiposity, but this was not apparent for the other measures of abdominal adiposity (DXA measures, waist circumference) or other cardiometablic risk factors. CONCLUSIONS: No strong evidence supports that DXA measures or abdominal measures of adiposity are better at predicting the prevalence of cardiometabolic risk factors in comparison to BMI. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/1471-2458-14-1239) contains supplementary material, which is available to authorized users. BioMed Central 2014-12-01 /pmc/articles/PMC4289237/ /pubmed/25438835 http://dx.doi.org/10.1186/1471-2458-14-1239 Text en © Kuper et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Kuper, Hannah Taylor, Amy Krishna, Kankipati Vijay Radha Ben-Shlomo, Yoav Gupta, Ruby Kulkarni, Bharati Prabhakaran, Dorairaj Davey Smith, George Wells, Jonathan Ebrahim, Shah Kinra, Sanjay Is vulnerability to cardiometabolic disease in Indians mediated by abdominal adiposity or higher body adiposity |
title | Is vulnerability to cardiometabolic disease in Indians mediated by abdominal adiposity or higher body adiposity |
title_full | Is vulnerability to cardiometabolic disease in Indians mediated by abdominal adiposity or higher body adiposity |
title_fullStr | Is vulnerability to cardiometabolic disease in Indians mediated by abdominal adiposity or higher body adiposity |
title_full_unstemmed | Is vulnerability to cardiometabolic disease in Indians mediated by abdominal adiposity or higher body adiposity |
title_short | Is vulnerability to cardiometabolic disease in Indians mediated by abdominal adiposity or higher body adiposity |
title_sort | is vulnerability to cardiometabolic disease in indians mediated by abdominal adiposity or higher body adiposity |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289237/ https://www.ncbi.nlm.nih.gov/pubmed/25438835 http://dx.doi.org/10.1186/1471-2458-14-1239 |
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