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Human breast cancer and lymph node metastases express Gb3 and can be targeted by STxB-vectorized chemotherapeutic compounds

BACKGROUND: The B-subunit of Shiga toxin (STxB) specifically binds to the glycosphingolipid Gb3 that is highly expressed on a number of human tumors and has been shown to target tumor cells in mouse models and ex vivo on primary colon carcinoma specimen. METHODS: Using a novel ex vivo STxB labeling...

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Detalles Bibliográficos
Autores principales:	Stimmer, Lev, Dehay, Sabrina, Nemati, Fariba, Massonnet, Gerald, Richon, Sophie, Decaudin, Didier, Klijanienko, Jerzy, Johannes, Ludger
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289340/ https://www.ncbi.nlm.nih.gov/pubmed/25476116 http://dx.doi.org/10.1186/1471-2407-14-916

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