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The role of the brain-derived neurotrophic factor genotype and parenting in early life in predicting externalizing and internalizing symptoms in children with attention-deficit hyperactivity disorder

BACKGROUND: We aimed to determine whether early parenting is associated with externalizing and internalizing symptoms in children with attention-deficit hyperactivity disorder (ADHD) and whether such an association is affected by the brain-derived neurotrophic factor (BDNF) val66met polymorphism. ME...

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Autores principales: Park, Subin, Kim, Bung-Nyun, Kim, Jae-Won, Jung, Yeon-Kyung, Lee, Jin, Shin, Min-Sup, Yoo, Hee Jeong, Cho, Soo-Churl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289369/
https://www.ncbi.nlm.nih.gov/pubmed/25425456
http://dx.doi.org/10.1186/1744-9081-10-43
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author Park, Subin
Kim, Bung-Nyun
Kim, Jae-Won
Jung, Yeon-Kyung
Lee, Jin
Shin, Min-Sup
Yoo, Hee Jeong
Cho, Soo-Churl
author_facet Park, Subin
Kim, Bung-Nyun
Kim, Jae-Won
Jung, Yeon-Kyung
Lee, Jin
Shin, Min-Sup
Yoo, Hee Jeong
Cho, Soo-Churl
author_sort Park, Subin
collection PubMed
description BACKGROUND: We aimed to determine whether early parenting is associated with externalizing and internalizing symptoms in children with attention-deficit hyperactivity disorder (ADHD) and whether such an association is affected by the brain-derived neurotrophic factor (BDNF) val66met polymorphism. METHODS: The participants included 92 patients with ADHD aged 6–15 years. Measures of parenting in early life and externalizing and internalizing symptoms and the genotype of the BDNF Val66Met polymorphism were obtained. RESULTS: The degree to which the baby’s autonomy was allowed was significantly and negatively correlated with the CDI scores in ADHD children (r = −0.38, p = 0.005). After adjusting for the child’s gender, the child’s age, the family’s gross annual income, and the maternal education level, there was a significant interaction for the BDNF genotype and mother’s positive feelings about caring in relation to the development of childhood anxiety/depression in ADHD children (F = 2.51, p = 0.011). CONCLUSIONS: Our results provide evidence of an interaction between the BDNF met allele and early parenting on the development of depression/anxiety symptoms.
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spelling pubmed-42893692015-01-11 The role of the brain-derived neurotrophic factor genotype and parenting in early life in predicting externalizing and internalizing symptoms in children with attention-deficit hyperactivity disorder Park, Subin Kim, Bung-Nyun Kim, Jae-Won Jung, Yeon-Kyung Lee, Jin Shin, Min-Sup Yoo, Hee Jeong Cho, Soo-Churl Behav Brain Funct Research BACKGROUND: We aimed to determine whether early parenting is associated with externalizing and internalizing symptoms in children with attention-deficit hyperactivity disorder (ADHD) and whether such an association is affected by the brain-derived neurotrophic factor (BDNF) val66met polymorphism. METHODS: The participants included 92 patients with ADHD aged 6–15 years. Measures of parenting in early life and externalizing and internalizing symptoms and the genotype of the BDNF Val66Met polymorphism were obtained. RESULTS: The degree to which the baby’s autonomy was allowed was significantly and negatively correlated with the CDI scores in ADHD children (r = −0.38, p = 0.005). After adjusting for the child’s gender, the child’s age, the family’s gross annual income, and the maternal education level, there was a significant interaction for the BDNF genotype and mother’s positive feelings about caring in relation to the development of childhood anxiety/depression in ADHD children (F = 2.51, p = 0.011). CONCLUSIONS: Our results provide evidence of an interaction between the BDNF met allele and early parenting on the development of depression/anxiety symptoms. BioMed Central 2014-11-25 /pmc/articles/PMC4289369/ /pubmed/25425456 http://dx.doi.org/10.1186/1744-9081-10-43 Text en © Park et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Park, Subin
Kim, Bung-Nyun
Kim, Jae-Won
Jung, Yeon-Kyung
Lee, Jin
Shin, Min-Sup
Yoo, Hee Jeong
Cho, Soo-Churl
The role of the brain-derived neurotrophic factor genotype and parenting in early life in predicting externalizing and internalizing symptoms in children with attention-deficit hyperactivity disorder
title The role of the brain-derived neurotrophic factor genotype and parenting in early life in predicting externalizing and internalizing symptoms in children with attention-deficit hyperactivity disorder
title_full The role of the brain-derived neurotrophic factor genotype and parenting in early life in predicting externalizing and internalizing symptoms in children with attention-deficit hyperactivity disorder
title_fullStr The role of the brain-derived neurotrophic factor genotype and parenting in early life in predicting externalizing and internalizing symptoms in children with attention-deficit hyperactivity disorder
title_full_unstemmed The role of the brain-derived neurotrophic factor genotype and parenting in early life in predicting externalizing and internalizing symptoms in children with attention-deficit hyperactivity disorder
title_short The role of the brain-derived neurotrophic factor genotype and parenting in early life in predicting externalizing and internalizing symptoms in children with attention-deficit hyperactivity disorder
title_sort role of the brain-derived neurotrophic factor genotype and parenting in early life in predicting externalizing and internalizing symptoms in children with attention-deficit hyperactivity disorder
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289369/
https://www.ncbi.nlm.nih.gov/pubmed/25425456
http://dx.doi.org/10.1186/1744-9081-10-43
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