The Effects of Wubeizi Ointment on the Proliferation of Keloid-Derived Fibroblasts

To evaluate the effectiveness of the Wubeizi (WBZ) ointment on keloid-derived fibroblasts. The primary cells of the keloid-derived fibroblasts were cultured and the effectiveness of the WBZ ointment at different concentrations was examined by MTT colorimetric methods on keloid-derived fibroblasts. T...

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Detalles Bibliográficos
Autores principales: Ding, Ji-cun, Tang, Zhi-ming, Zhai, Xiao-xiang, Chen, Xiang-hui, Li, Jing-guo, Zhang, Cui-xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2014
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289516/
https://www.ncbi.nlm.nih.gov/pubmed/25343939
http://dx.doi.org/10.1007/s12013-014-0219-7
Descripción
Sumario:To evaluate the effectiveness of the Wubeizi (WBZ) ointment on keloid-derived fibroblasts. The primary cells of the keloid-derived fibroblasts were cultured and the effectiveness of the WBZ ointment at different concentrations was examined by MTT colorimetric methods on keloid-derived fibroblasts. The WBZ ointment showed inhibitory effects on proliferating the keloid-derived fibroblasts (P < 0.01)in a time- and dose-dependent manner. The proportion of cells in S stage was significantly higher in each of the WBZ ointment group than in the control group (P<0.01), and the proportion of G(2) + M stage cells was significantly lower than that of control group, which was statistically significant (P < 0.01).The inhibitory effects of the S and G(2) + M stage increased with higher drug concentrations (P < 0.05). Conclusion: The WBZ ointment can inhibit the proliferation of the keloid-derived fibroblasts in a time- and dose- dependent manner.

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