Modulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for hepatocellular carcinoma therapy

BACKGROUND: Functional disturbances of the endoplasmic reticulum (ER) lead to activation of the unfolded protein response (UPR), which is involved in the consecutive steps of carcinogenesis. In human hepatocellular carcinoma (HCC), the UPR is shown to be activated; however, little is known about the...

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Detalles Bibliográficos
Autores principales: Vandewynckel, Yves-Paul, Laukens, Debby, Bogaerts, Eliene, Paridaens, Annelies, Van den Bussche, Anja, Verhelst, Xavier, Van Steenkiste, Christophe, Descamps, Benedicte, Vanhove, Chris, Libbrecht, Louis, De Rycke, Riet, Lambrecht, Bart N., Geerts, Anja, Janssens, Sophie, Van Vlierberghe, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer India 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289530/
https://www.ncbi.nlm.nih.gov/pubmed/25598862
http://dx.doi.org/10.1007/s12072-014-9582-0

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