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High Molecular Weight (HMW): total adiponectin ratio is low in hiv-infected women receiving protease inhibitors

BACKGROUND: At the time of the study, the HIV-treatment policy in South Africa included highly active antiretroviral therapy (HAART) regimens 1 (nucleotide reverse transcriptase inhibitors (NRTIs) only), and 2 (protease inhibitors (PI) and NRTIs). HAART is associated with the lipodystrophy syndrome,...

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Autores principales: Omar, Fierdoz, Dave, Joel A, King, Judy A, Levitt, Naomi S, Pillay, Tahir S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289558/
https://www.ncbi.nlm.nih.gov/pubmed/25580091
http://dx.doi.org/10.1186/1472-6890-14-46
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author Omar, Fierdoz
Dave, Joel A
King, Judy A
Levitt, Naomi S
Pillay, Tahir S
author_facet Omar, Fierdoz
Dave, Joel A
King, Judy A
Levitt, Naomi S
Pillay, Tahir S
author_sort Omar, Fierdoz
collection PubMed
description BACKGROUND: At the time of the study, the HIV-treatment policy in South Africa included highly active antiretroviral therapy (HAART) regimens 1 (nucleotide reverse transcriptase inhibitors (NRTIs) only), and 2 (protease inhibitors (PI) and NRTIs). HAART is associated with the lipodystrophy syndrome, insulin resistance and reduced total adiponectin (TA) levels. The high molecular weight (HMW):TA ratio is a superior marker of insulin resistance. The aim of this study was to establish whether HMW:TA ratios are low in patients on PIs and whether they correlate with insulin resistance. METHODS: This was a cross-sectional study undertaken in an antiretroviral clinic at a tertiary hospital. The participants were 66 HIV-infected females: 22 were on regimen 2 (PI group), 22 on regimen 1 (non-PI) and 22 treatment naïve (TN), matched for BMI and age. Patients with a history of diabetes or impaired glucose tolerance were excluded. Serum adiponectin multimers were analysed using the AlpcoTM Adiponectin (Multimeric) enzyme immunoassay. Waist hip ratios (WHR), glucose and insulin levels were assessed, and HOMA-IR and QUICKI calculated. Data were analysed non-parametrically and multivariate analysis was performed. RESULTS: TA and HMW levels were lower in the treatment groups than in the TN group. HMW:TA was lower in the PI than in the non-PI and TN groups, and in the non-PI than in the TN groups. HMW:TA correlated negatively with waist, insulin and HOMA-IR, independently of BMI and duration of therapy. HOMA-IR and QUICKI did not differ among the groups. CONCLUSION: HMW:TA is significantly decreased with HAART (particularly with PIs, but also with non-PIs) and may be a more sensitive marker of insulin resistance in these patients than conventional markers or HMW and total adiponectin individually.
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spelling pubmed-42895582015-01-12 High Molecular Weight (HMW): total adiponectin ratio is low in hiv-infected women receiving protease inhibitors Omar, Fierdoz Dave, Joel A King, Judy A Levitt, Naomi S Pillay, Tahir S BMC Clin Pathol Research Article BACKGROUND: At the time of the study, the HIV-treatment policy in South Africa included highly active antiretroviral therapy (HAART) regimens 1 (nucleotide reverse transcriptase inhibitors (NRTIs) only), and 2 (protease inhibitors (PI) and NRTIs). HAART is associated with the lipodystrophy syndrome, insulin resistance and reduced total adiponectin (TA) levels. The high molecular weight (HMW):TA ratio is a superior marker of insulin resistance. The aim of this study was to establish whether HMW:TA ratios are low in patients on PIs and whether they correlate with insulin resistance. METHODS: This was a cross-sectional study undertaken in an antiretroviral clinic at a tertiary hospital. The participants were 66 HIV-infected females: 22 were on regimen 2 (PI group), 22 on regimen 1 (non-PI) and 22 treatment naïve (TN), matched for BMI and age. Patients with a history of diabetes or impaired glucose tolerance were excluded. Serum adiponectin multimers were analysed using the AlpcoTM Adiponectin (Multimeric) enzyme immunoassay. Waist hip ratios (WHR), glucose and insulin levels were assessed, and HOMA-IR and QUICKI calculated. Data were analysed non-parametrically and multivariate analysis was performed. RESULTS: TA and HMW levels were lower in the treatment groups than in the TN group. HMW:TA was lower in the PI than in the non-PI and TN groups, and in the non-PI than in the TN groups. HMW:TA correlated negatively with waist, insulin and HOMA-IR, independently of BMI and duration of therapy. HOMA-IR and QUICKI did not differ among the groups. CONCLUSION: HMW:TA is significantly decreased with HAART (particularly with PIs, but also with non-PIs) and may be a more sensitive marker of insulin resistance in these patients than conventional markers or HMW and total adiponectin individually. BioMed Central 2014-12-16 /pmc/articles/PMC4289558/ /pubmed/25580091 http://dx.doi.org/10.1186/1472-6890-14-46 Text en © Omar et al.; licensee BioMed Central. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Omar, Fierdoz
Dave, Joel A
King, Judy A
Levitt, Naomi S
Pillay, Tahir S
High Molecular Weight (HMW): total adiponectin ratio is low in hiv-infected women receiving protease inhibitors
title High Molecular Weight (HMW): total adiponectin ratio is low in hiv-infected women receiving protease inhibitors
title_full High Molecular Weight (HMW): total adiponectin ratio is low in hiv-infected women receiving protease inhibitors
title_fullStr High Molecular Weight (HMW): total adiponectin ratio is low in hiv-infected women receiving protease inhibitors
title_full_unstemmed High Molecular Weight (HMW): total adiponectin ratio is low in hiv-infected women receiving protease inhibitors
title_short High Molecular Weight (HMW): total adiponectin ratio is low in hiv-infected women receiving protease inhibitors
title_sort high molecular weight (hmw): total adiponectin ratio is low in hiv-infected women receiving protease inhibitors
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289558/
https://www.ncbi.nlm.nih.gov/pubmed/25580091
http://dx.doi.org/10.1186/1472-6890-14-46
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